Prevalence of lesions detected at upper endoscopy: An Italian survey

Angelo Zullo, Gianluca Esposito, Lorenzo Ridola, Cesare Hassan, Edith Lahner, Francesco Perri, Maria Antonietta Bianco, Vincenzo De Francesco, Elisabetta Buscarini, Emilio Di Giulio, Bruno Annibale

Research output: Contribution to journalArticlepeer-review


Background: Prevalence of gastroduodenal lesions is changing in the last decades. Prevalence of Helicobacter pylori infection, non-steroidal anti-inflammatory drugs (NSAIDs), and proton pump inhibitor (PPI) therapy may be involved in such a phenomenon.We assessed gastroduodenal lesions prevalence in a nationwide study.

Materials and methods: Consecutive patients who underwent upper endoscopy for the first time in 24 Italian centres between January 2012 and 31 March 2012 were enrolled. Prevalence of gastric ulcer (GU), duodenal ulcer (DU), gastric erosions (GE), duodenal erosions (DE), gastric polyp (GP), Barrett's oesophagus (BE), and neoplasia was assessed.

Results: Overall, 1054 (M/F: 388/666; Mean age: 57.5 ± 5 years) patients were enrolled. H. pylori infection was detected in 356 (33.9%) patients, 358 (34%)were takingNSAIDs, and 532 (50.5%) PPIs. PPI therapy was associated with a significantly lower H. pylori detection rate (27.8% vs 39.8%; OR: 0.6, 95% CI 0.450.77; P <0.001). GU, DU, GE, DE, GP and BE were detected in 17 (1.6%), 13 (1.2%), 150 (14.2%), 50 (4.7%), 51 (4.8%) and 17 (1.6%), respectively. Moreover, 3 (0.3%) distal gastric cancers were observed. H. pylori infection remained the most prevalent factor for all gastroduodenal lesions, but gastric polyp. One third of patients with GU and GE were taking only NSAIDs therapy.

Conclusions: The prevalence of peptic ulcerwas very low(

Original languageEnglish
Pages (from-to)772-776
Number of pages5
JournalEuropean Journal of Internal Medicine
Issue number8
Publication statusPublished - Oct 1 2014


  • Erosions
  • Peptic ulcer
  • Polyp
  • Proton pump inhibitor therapy
  • Upper endoscopy

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)


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