TY - JOUR
T1 - Prevalence of limb muscle dysfunction in patients with chronic obstructive pulmonary disease admitted to a pulmonary rehabilitation centre
AU - Carrai, Riccardo
AU - Scano, Giorgio
AU - Gigliotti, Francesco
AU - Romagnoli, Isabella
AU - Lanini, Barbara
AU - Coli, Claudia
AU - Grippo, Antonello
PY - 2012/11
Y1 - 2012/11
N2 - Objective: Assessment of needle electromyography (nEMG) may complement previous data on limb muscle dysfunction (LMD) in patients with chronic obstructive pulmonary disease (COPD). We attempted to quantify the prevalence of LMD and assess its impact on clinical outcomes in patients admitted to a rehabilitation programme. Methods: One hundred and thirty-two clinically stable patients were consecutively enrolled. They underwent spirometry and the following primary outcomes were evaluated: St. George respiratory questionnaire (SGRQ), functional independence measure (FIM) questionnaire and a 6-min walking test (6MWT). One hundred and fourteen patients underwent nEMG. The frequency of LMD was related to COPD stage and chronic dyspnoea. Results: nEMG detected myopathic signs in 36.8% of the patients. LMD was found even in early stages of COPD. FIM and 6MWT were significantly lower, and SGRQ tended to be higher at each COPD stage in patients with LMD. However, the 6MWT rate of decay across the COPD stages was similar in patients with and without LMD. Conclusions: LMD might not be restricted to patients with severe airway obstruction and regardless of COPD stage, contributes to functional limitation of these patients. Significance: The putative role of LMD in motor limitations indicates the need to assess it early onto better organise a specific training programme as part of general pulmonary rehabilitation in COPD patients.
AB - Objective: Assessment of needle electromyography (nEMG) may complement previous data on limb muscle dysfunction (LMD) in patients with chronic obstructive pulmonary disease (COPD). We attempted to quantify the prevalence of LMD and assess its impact on clinical outcomes in patients admitted to a rehabilitation programme. Methods: One hundred and thirty-two clinically stable patients were consecutively enrolled. They underwent spirometry and the following primary outcomes were evaluated: St. George respiratory questionnaire (SGRQ), functional independence measure (FIM) questionnaire and a 6-min walking test (6MWT). One hundred and fourteen patients underwent nEMG. The frequency of LMD was related to COPD stage and chronic dyspnoea. Results: nEMG detected myopathic signs in 36.8% of the patients. LMD was found even in early stages of COPD. FIM and 6MWT were significantly lower, and SGRQ tended to be higher at each COPD stage in patients with LMD. However, the 6MWT rate of decay across the COPD stages was similar in patients with and without LMD. Conclusions: LMD might not be restricted to patients with severe airway obstruction and regardless of COPD stage, contributes to functional limitation of these patients. Significance: The putative role of LMD in motor limitations indicates the need to assess it early onto better organise a specific training programme as part of general pulmonary rehabilitation in COPD patients.
KW - 6min Walking test
KW - EMG
KW - Functional independence measure
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U2 - 10.1016/j.clinph.2012.04.009
DO - 10.1016/j.clinph.2012.04.009
M3 - Article
C2 - 22617816
AN - SCOPUS:84866987690
VL - 123
SP - 2306
EP - 2311
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -