Prevalence of malnutrition in patients at first medical oncology visit

The PreMiO study

Maurizio Muscaritoli, Simone Lucia, Alessio Farcomeni, Vito Lorusso, Valeria Saracino, Carlo Barone, Francesca Plastino, Stefania Gori, Roberto Magarotto, Giacomo Carteni, Bruno Chiurazzi, Ida Pavese, Luca Marchetti, Vittorina Zagonel, Eleonora Bergo, Giuseppe Tonini, Marco Imperatori, Carmelo Iacono, Luigi Maiorana, Carmine Pinto & 31 others Daniela Rubino, Luigi Cavanna, Roberto Di Cicilia, Teresa Gamucci, Silvia Quadrini, Salvatore Palazzo, Stefano Minardi, Marco Merlano, Giuseppe Colucci, Paolo Marchetti, L. Fioretto, G. Cipriani, S. Barni, V. Lonati, A. Frassoldati, G. C. Surace, G. Porzio, F. Martella, G. Altavilla, M. C. Santarpia, P. Pronzato, A. Levaggi, A. Contu, M. Contu, V. Adamo, R. Berenato, F. Marchetti, A. Pellegrino, S. Violante, M. Guida, on behalf of the PreMiO Study Group

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: In cancer patients, malnutrition is associated with treatment toxicity, complications, reduced physical functioning, and decreased survival. The Prevalence of Malnutrition in Oncology (PreMiO) study identified malnutrition or its risk among cancer patients making their first medical oncology visit. Innovatively, oncologists, not nutritionists, evaluated the nutritional status of the patients in this study. Methods: PreMiO was a prospective, observational study conducted at 22 medical oncology centers across Italy. For inclusion, adult patients (> 18 years) had a solid tumor diagnosis, were treatment-naive, and had a life expectancy > 3 months. Malnutrition was identified by the Mini Nutritional Assessment (MNA), appetite status with a visual analog scale (VAS), and appetite loss with a modified version of Anorexia-Cachexia Subscale (AC/S-12) of the Functional Assessment of Anorexia- Cachexia Therapy (FAACT). Findings: Of patients enrolled (N=1,952), 51% had nutritional impairment; 9% were overtly malnourished, and 43% were at risk for malnutrition. Severity of malnutrition was positively correlated with the stage of cancer. Over 40% of patients were experiencing anorexia, as reported in the VAS and FAACT questionnaire. During the prior six months, 64% of patients lost weight (1-10 kg). Interpretation: Malnutrition, anorexia, and weight loss are common in cancer patients, even at their first visit to a medical oncology center.

Original languageEnglish
Pages (from-to)79884-79896
Number of pages13
JournalOncotarget
Volume8
Issue number45
DOIs
Publication statusPublished - 2017

Fingerprint

Medical Oncology
Malnutrition
Anorexia
Cachexia
Appetite
Neoplasms
Visual Analog Scale
Nutrition Assessment
Nutritionists
Therapeutics
Life Expectancy
Nutritional Status
Italy
Observational Studies
Weight Loss
Prospective Studies
Weights and Measures
Survival

Keywords

  • Cachexia
  • Cancer
  • Malnutrition
  • Oncology
  • Sarcopenia

ASJC Scopus subject areas

  • Oncology

Cite this

Muscaritoli, M., Lucia, S., Farcomeni, A., Lorusso, V., Saracino, V., Barone, C., ... on behalf of the PreMiO Study Group (2017). Prevalence of malnutrition in patients at first medical oncology visit: The PreMiO study. Oncotarget, 8(45), 79884-79896. https://doi.org/10.18632/oncotarget.20168

Prevalence of malnutrition in patients at first medical oncology visit : The PreMiO study. / Muscaritoli, Maurizio; Lucia, Simone; Farcomeni, Alessio; Lorusso, Vito; Saracino, Valeria; Barone, Carlo; Plastino, Francesca; Gori, Stefania; Magarotto, Roberto; Carteni, Giacomo; Chiurazzi, Bruno; Pavese, Ida; Marchetti, Luca; Zagonel, Vittorina; Bergo, Eleonora; Tonini, Giuseppe; Imperatori, Marco; Iacono, Carmelo; Maiorana, Luigi; Pinto, Carmine; Rubino, Daniela; Cavanna, Luigi; Di Cicilia, Roberto; Gamucci, Teresa; Quadrini, Silvia; Palazzo, Salvatore; Minardi, Stefano; Merlano, Marco; Colucci, Giuseppe; Marchetti, Paolo; Fioretto, L.; Cipriani, G.; Barni, S.; Lonati, V.; Frassoldati, A.; Surace, G. C.; Porzio, G.; Martella, F.; Altavilla, G.; Santarpia, M. C.; Pronzato, P.; Levaggi, A.; Contu, A.; Contu, M.; Adamo, V.; Berenato, R.; Marchetti, F.; Pellegrino, A.; Violante, S.; Guida, M.; on behalf of the PreMiO Study Group.

In: Oncotarget, Vol. 8, No. 45, 2017, p. 79884-79896.

Research output: Contribution to journalArticle

Muscaritoli, M, Lucia, S, Farcomeni, A, Lorusso, V, Saracino, V, Barone, C, Plastino, F, Gori, S, Magarotto, R, Carteni, G, Chiurazzi, B, Pavese, I, Marchetti, L, Zagonel, V, Bergo, E, Tonini, G, Imperatori, M, Iacono, C, Maiorana, L, Pinto, C, Rubino, D, Cavanna, L, Di Cicilia, R, Gamucci, T, Quadrini, S, Palazzo, S, Minardi, S, Merlano, M, Colucci, G, Marchetti, P, Fioretto, L, Cipriani, G, Barni, S, Lonati, V, Frassoldati, A, Surace, GC, Porzio, G, Martella, F, Altavilla, G, Santarpia, MC, Pronzato, P, Levaggi, A, Contu, A, Contu, M, Adamo, V, Berenato, R, Marchetti, F, Pellegrino, A, Violante, S, Guida, M & on behalf of the PreMiO Study Group 2017, 'Prevalence of malnutrition in patients at first medical oncology visit: The PreMiO study', Oncotarget, vol. 8, no. 45, pp. 79884-79896. https://doi.org/10.18632/oncotarget.20168
Muscaritoli, Maurizio ; Lucia, Simone ; Farcomeni, Alessio ; Lorusso, Vito ; Saracino, Valeria ; Barone, Carlo ; Plastino, Francesca ; Gori, Stefania ; Magarotto, Roberto ; Carteni, Giacomo ; Chiurazzi, Bruno ; Pavese, Ida ; Marchetti, Luca ; Zagonel, Vittorina ; Bergo, Eleonora ; Tonini, Giuseppe ; Imperatori, Marco ; Iacono, Carmelo ; Maiorana, Luigi ; Pinto, Carmine ; Rubino, Daniela ; Cavanna, Luigi ; Di Cicilia, Roberto ; Gamucci, Teresa ; Quadrini, Silvia ; Palazzo, Salvatore ; Minardi, Stefano ; Merlano, Marco ; Colucci, Giuseppe ; Marchetti, Paolo ; Fioretto, L. ; Cipriani, G. ; Barni, S. ; Lonati, V. ; Frassoldati, A. ; Surace, G. C. ; Porzio, G. ; Martella, F. ; Altavilla, G. ; Santarpia, M. C. ; Pronzato, P. ; Levaggi, A. ; Contu, A. ; Contu, M. ; Adamo, V. ; Berenato, R. ; Marchetti, F. ; Pellegrino, A. ; Violante, S. ; Guida, M. ; on behalf of the PreMiO Study Group. / Prevalence of malnutrition in patients at first medical oncology visit : The PreMiO study. In: Oncotarget. 2017 ; Vol. 8, No. 45. pp. 79884-79896.
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abstract = "Background: In cancer patients, malnutrition is associated with treatment toxicity, complications, reduced physical functioning, and decreased survival. The Prevalence of Malnutrition in Oncology (PreMiO) study identified malnutrition or its risk among cancer patients making their first medical oncology visit. Innovatively, oncologists, not nutritionists, evaluated the nutritional status of the patients in this study. Methods: PreMiO was a prospective, observational study conducted at 22 medical oncology centers across Italy. For inclusion, adult patients (> 18 years) had a solid tumor diagnosis, were treatment-naive, and had a life expectancy > 3 months. Malnutrition was identified by the Mini Nutritional Assessment (MNA), appetite status with a visual analog scale (VAS), and appetite loss with a modified version of Anorexia-Cachexia Subscale (AC/S-12) of the Functional Assessment of Anorexia- Cachexia Therapy (FAACT). Findings: Of patients enrolled (N=1,952), 51{\%} had nutritional impairment; 9{\%} were overtly malnourished, and 43{\%} were at risk for malnutrition. Severity of malnutrition was positively correlated with the stage of cancer. Over 40{\%} of patients were experiencing anorexia, as reported in the VAS and FAACT questionnaire. During the prior six months, 64{\%} of patients lost weight (1-10 kg). Interpretation: Malnutrition, anorexia, and weight loss are common in cancer patients, even at their first visit to a medical oncology center.",
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author = "Maurizio Muscaritoli and Simone Lucia and Alessio Farcomeni and Vito Lorusso and Valeria Saracino and Carlo Barone and Francesca Plastino and Stefania Gori and Roberto Magarotto and Giacomo Carteni and Bruno Chiurazzi and Ida Pavese and Luca Marchetti and Vittorina Zagonel and Eleonora Bergo and Giuseppe Tonini and Marco Imperatori and Carmelo Iacono and Luigi Maiorana and Carmine Pinto and Daniela Rubino and Luigi Cavanna and {Di Cicilia}, Roberto and Teresa Gamucci and Silvia Quadrini and Salvatore Palazzo and Stefano Minardi and Marco Merlano and Giuseppe Colucci and Paolo Marchetti and L. Fioretto and G. Cipriani and S. Barni and V. Lonati and A. Frassoldati and Surace, {G. C.} and G. Porzio and F. Martella and G. Altavilla and Santarpia, {M. C.} and P. Pronzato and A. Levaggi and A. Contu and M. Contu and V. Adamo and R. Berenato and F. Marchetti and A. Pellegrino and S. Violante and M. Guida and {on behalf of the PreMiO Study Group}",
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T1 - Prevalence of malnutrition in patients at first medical oncology visit

T2 - The PreMiO study

AU - Muscaritoli, Maurizio

AU - Lucia, Simone

AU - Farcomeni, Alessio

AU - Lorusso, Vito

AU - Saracino, Valeria

AU - Barone, Carlo

AU - Plastino, Francesca

AU - Gori, Stefania

AU - Magarotto, Roberto

AU - Carteni, Giacomo

AU - Chiurazzi, Bruno

AU - Pavese, Ida

AU - Marchetti, Luca

AU - Zagonel, Vittorina

AU - Bergo, Eleonora

AU - Tonini, Giuseppe

AU - Imperatori, Marco

AU - Iacono, Carmelo

AU - Maiorana, Luigi

AU - Pinto, Carmine

AU - Rubino, Daniela

AU - Cavanna, Luigi

AU - Di Cicilia, Roberto

AU - Gamucci, Teresa

AU - Quadrini, Silvia

AU - Palazzo, Salvatore

AU - Minardi, Stefano

AU - Merlano, Marco

AU - Colucci, Giuseppe

AU - Marchetti, Paolo

AU - Fioretto, L.

AU - Cipriani, G.

AU - Barni, S.

AU - Lonati, V.

AU - Frassoldati, A.

AU - Surace, G. C.

AU - Porzio, G.

AU - Martella, F.

AU - Altavilla, G.

AU - Santarpia, M. C.

AU - Pronzato, P.

AU - Levaggi, A.

AU - Contu, A.

AU - Contu, M.

AU - Adamo, V.

AU - Berenato, R.

AU - Marchetti, F.

AU - Pellegrino, A.

AU - Violante, S.

AU - Guida, M.

AU - on behalf of the PreMiO Study Group

PY - 2017

Y1 - 2017

N2 - Background: In cancer patients, malnutrition is associated with treatment toxicity, complications, reduced physical functioning, and decreased survival. The Prevalence of Malnutrition in Oncology (PreMiO) study identified malnutrition or its risk among cancer patients making their first medical oncology visit. Innovatively, oncologists, not nutritionists, evaluated the nutritional status of the patients in this study. Methods: PreMiO was a prospective, observational study conducted at 22 medical oncology centers across Italy. For inclusion, adult patients (> 18 years) had a solid tumor diagnosis, were treatment-naive, and had a life expectancy > 3 months. Malnutrition was identified by the Mini Nutritional Assessment (MNA), appetite status with a visual analog scale (VAS), and appetite loss with a modified version of Anorexia-Cachexia Subscale (AC/S-12) of the Functional Assessment of Anorexia- Cachexia Therapy (FAACT). Findings: Of patients enrolled (N=1,952), 51% had nutritional impairment; 9% were overtly malnourished, and 43% were at risk for malnutrition. Severity of malnutrition was positively correlated with the stage of cancer. Over 40% of patients were experiencing anorexia, as reported in the VAS and FAACT questionnaire. During the prior six months, 64% of patients lost weight (1-10 kg). Interpretation: Malnutrition, anorexia, and weight loss are common in cancer patients, even at their first visit to a medical oncology center.

AB - Background: In cancer patients, malnutrition is associated with treatment toxicity, complications, reduced physical functioning, and decreased survival. The Prevalence of Malnutrition in Oncology (PreMiO) study identified malnutrition or its risk among cancer patients making their first medical oncology visit. Innovatively, oncologists, not nutritionists, evaluated the nutritional status of the patients in this study. Methods: PreMiO was a prospective, observational study conducted at 22 medical oncology centers across Italy. For inclusion, adult patients (> 18 years) had a solid tumor diagnosis, were treatment-naive, and had a life expectancy > 3 months. Malnutrition was identified by the Mini Nutritional Assessment (MNA), appetite status with a visual analog scale (VAS), and appetite loss with a modified version of Anorexia-Cachexia Subscale (AC/S-12) of the Functional Assessment of Anorexia- Cachexia Therapy (FAACT). Findings: Of patients enrolled (N=1,952), 51% had nutritional impairment; 9% were overtly malnourished, and 43% were at risk for malnutrition. Severity of malnutrition was positively correlated with the stage of cancer. Over 40% of patients were experiencing anorexia, as reported in the VAS and FAACT questionnaire. During the prior six months, 64% of patients lost weight (1-10 kg). Interpretation: Malnutrition, anorexia, and weight loss are common in cancer patients, even at their first visit to a medical oncology center.

KW - Cachexia

KW - Cancer

KW - Malnutrition

KW - Oncology

KW - Sarcopenia

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