Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection

Rinaldo Pellicano, Giovanni Antonio Touscoz, Antonina Smedile, Mara Berrutti, Giorgio Saracco, Alessandro Repici, Antonio Ponzetto, Mario Rizzetto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Autoimmunity, a feature of chronic infection by Helicobacter pylori, is first directed against gastric cells but is also associated with extragastric diseases. The aim of the present work was to look for the influence of the infection on induction of non-organ-specific autoantibodies (NOSAs). We compared 49 patients (28 males and 21 females; age range, 36-72 years; mean, 61 ± 4.6 years) suffering from duodenal ulcer and H. pylori infection (Group A) to 38 subjects (20 male, 18 female; age range, 40-78 years; mean, 63 ± 3.8 years) affected by duodenal ulcer related to the assumption of nonsteroidal antiinflammatory drugs (Group B). H. pylori infection was diagnosed by histology, 13C-urea breath test, and serum IgG antibodies. Autoimmunitary pattern was demonstrated by the presence of NOSAs in serum. Antinuclear (ANA), anti-smooth muscle (SMA), and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present in 5 of 49 (10.2%), 2 of 49 (4%), and 0 Group A patients, respectively. In Group B, ANA was present in 3 of 38 (7.9%), SMA in 3 of 38 (7.9%), and anti-LKM-1 in 0 patients. The difference was not statistically significant. In this population, H. pylori infection is not associated with an increased prevalence of NOSAs.

Original languageEnglish
Pages (from-to)395-398
Number of pages4
JournalDigestive Diseases and Sciences
Volume49
Issue number3
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Helicobacter Infections
Duodenal Ulcer
Helicobacter pylori
Autoantibodies
Kidney
Breath Tests
Antibodies
Liver
Infection
Serum
Autoimmunity
Smooth Muscle
Urea
Stomach
Histology
Anti-Inflammatory Agents
Immunoglobulin G
Pharmaceutical Preparations
Population

Keywords

  • Autoantibodies
  • Autoimmunity
  • Helicobacter pylori
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection. / Pellicano, Rinaldo; Touscoz, Giovanni Antonio; Smedile, Antonina; Berrutti, Mara; Saracco, Giorgio; Repici, Alessandro; Ponzetto, Antonio; Rizzetto, Mario.

In: Digestive Diseases and Sciences, Vol. 49, No. 3, 03.2004, p. 395-398.

Research output: Contribution to journalArticle

Pellicano, Rinaldo ; Touscoz, Giovanni Antonio ; Smedile, Antonina ; Berrutti, Mara ; Saracco, Giorgio ; Repici, Alessandro ; Ponzetto, Antonio ; Rizzetto, Mario. / Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection. In: Digestive Diseases and Sciences. 2004 ; Vol. 49, No. 3. pp. 395-398.
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