Prevalence of Paget's disease of bone in Italy

Luigi Gennari, Marco Di Stefano, Daniela Merlotti, Nicola Giordano, Giuseppe Martini, Cristina Tamone, Roberto Zatteri, Roberto De Lucchi, Carlo Baldi, Angelo Vattimo, Silvia Capoccia, Luca Burroni, Simone Geraci, Vincenzo De Paola, Anna Calabrò, Annalisa Avanzati, Giancarlo Isaia, Ranuccio Nuti

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

We examined the prevalence of PDB in Italy from radiological, scintigraphic, and biochemical surveys in two Italian towns. Prevalence rates varied from 0.7.% to 2.4%, were higher in males than in females, and slightly differed between the two towns. Unlike previous studies in populations of British descent, no secular trend for a decreasing prevalence emerged. Introduction: Clinical, radiological, and necropsy data from different countries suggested pronounced geographical variations in the prevalence of Paget's disease of bone (PDB). Despite the impact of the disease on the population, there are limited data on the prevalence of PDB in Italy. Materials and Methods: The objective of this study was to estimate the prevalence of PDB in the district of Siena (Central Italy) and Turin (Northern Italy) from radiological, biochemical, and scintigraphic surveys. We examined a sample of 1778 consecutive pelvic radiographs performed between 1999 and 2000 at the Hospital Radiology Unit in Siena and 6609 pelvic radiographs performed in 1986-1987, 1992-1993, and 1999-2002 from the Radiology Department of Molinette Hospital in Turin. In Siena, 7906 consecutive 99mTC-MDP bone scans performed over a 4-year period (January 2000 to May 2004) were also screened for the presence of PDB, and the prevalence of elevated alkaline phosphatase (ALP) levels (>300 UI/liter) was estimated from 7449 computerized medical records over a 3-year period (January 2000 to February 2003). The finding of PDB on the pelvic radiograph and bone scan was based on standardized radiological criteria. Results: At the end of the radiological surveys, 16/1778 pelvic PDB cases (8 males and 8 females) were observed in Siena and 41/6609 (27 males and 14 females) in Turin. The crude prevalence of the disease was 0.89% in Siena and 0.62% in Turin. Given that pelvic involvement is commonly described in 60-90% of PDB patients, the estimated overall prevalence of PDB ranged from 1.0% to 1.5% in Siena and from 0.7% to 1.0% in Turin. No decrease in the prevalence of PDB was evident after comparison of prevalence rates from different periods. Biochemical analyses showed 296/7449 subjects with elevated ALP levels and normal liver enzymes, 87 of whom had confirmed diagnosis of PDB. The estimated prevalence of biochemical PDB was 1.5%. The scintigraphic survey showed a PDB prevalence of 194/7906 (2.4%), which was significantly higher than the radiological and biochemical estimates. Conclusions: Our surveys suggest that PDB in Italy has an estimated prevalence of at least 1%, comparable with that observed in United States and other European countries, but lower than that described in Britain and New Zealand. No secular trend for a decreasing prevalence of PDB was observed.

Original languageEnglish
Pages (from-to)1845-1850
Number of pages6
JournalJournal of Bone and Mineral Research
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Osteitis Deformans
Italy
Alkaline Phosphatase
Hospital Radiology Department
Computerized Medical Records Systems
Pelvic Bones
Technetium Tc 99m Medronate
Hospital Units

Keywords

  • Alkaline phosphatase
  • Bone scintigraphy
  • Epidemiology
  • Paget's disease of bone
  • Pelvic X-ray

ASJC Scopus subject areas

  • Surgery

Cite this

Gennari, L., Stefano, M. D., Merlotti, D., Giordano, N., Martini, G., Tamone, C., ... Nuti, R. (2005). Prevalence of Paget's disease of bone in Italy. Journal of Bone and Mineral Research, 20(10), 1845-1850. https://doi.org/10.1359/JBMR.050518

Prevalence of Paget's disease of bone in Italy. / Gennari, Luigi; Stefano, Marco Di; Merlotti, Daniela; Giordano, Nicola; Martini, Giuseppe; Tamone, Cristina; Zatteri, Roberto; De Lucchi, Roberto; Baldi, Carlo; Vattimo, Angelo; Capoccia, Silvia; Burroni, Luca; Geraci, Simone; De Paola, Vincenzo; Calabrò, Anna; Avanzati, Annalisa; Isaia, Giancarlo; Nuti, Ranuccio.

In: Journal of Bone and Mineral Research, Vol. 20, No. 10, 10.2005, p. 1845-1850.

Research output: Contribution to journalArticle

Gennari, L, Stefano, MD, Merlotti, D, Giordano, N, Martini, G, Tamone, C, Zatteri, R, De Lucchi, R, Baldi, C, Vattimo, A, Capoccia, S, Burroni, L, Geraci, S, De Paola, V, Calabrò, A, Avanzati, A, Isaia, G & Nuti, R 2005, 'Prevalence of Paget's disease of bone in Italy', Journal of Bone and Mineral Research, vol. 20, no. 10, pp. 1845-1850. https://doi.org/10.1359/JBMR.050518
Gennari L, Stefano MD, Merlotti D, Giordano N, Martini G, Tamone C et al. Prevalence of Paget's disease of bone in Italy. Journal of Bone and Mineral Research. 2005 Oct;20(10):1845-1850. https://doi.org/10.1359/JBMR.050518
Gennari, Luigi ; Stefano, Marco Di ; Merlotti, Daniela ; Giordano, Nicola ; Martini, Giuseppe ; Tamone, Cristina ; Zatteri, Roberto ; De Lucchi, Roberto ; Baldi, Carlo ; Vattimo, Angelo ; Capoccia, Silvia ; Burroni, Luca ; Geraci, Simone ; De Paola, Vincenzo ; Calabrò, Anna ; Avanzati, Annalisa ; Isaia, Giancarlo ; Nuti, Ranuccio. / Prevalence of Paget's disease of bone in Italy. In: Journal of Bone and Mineral Research. 2005 ; Vol. 20, No. 10. pp. 1845-1850.
@article{cbe22fd92c0c4a7884d3f8eec8f083d3,
title = "Prevalence of Paget's disease of bone in Italy",
abstract = "We examined the prevalence of PDB in Italy from radiological, scintigraphic, and biochemical surveys in two Italian towns. Prevalence rates varied from 0.7.{\%} to 2.4{\%}, were higher in males than in females, and slightly differed between the two towns. Unlike previous studies in populations of British descent, no secular trend for a decreasing prevalence emerged. Introduction: Clinical, radiological, and necropsy data from different countries suggested pronounced geographical variations in the prevalence of Paget's disease of bone (PDB). Despite the impact of the disease on the population, there are limited data on the prevalence of PDB in Italy. Materials and Methods: The objective of this study was to estimate the prevalence of PDB in the district of Siena (Central Italy) and Turin (Northern Italy) from radiological, biochemical, and scintigraphic surveys. We examined a sample of 1778 consecutive pelvic radiographs performed between 1999 and 2000 at the Hospital Radiology Unit in Siena and 6609 pelvic radiographs performed in 1986-1987, 1992-1993, and 1999-2002 from the Radiology Department of Molinette Hospital in Turin. In Siena, 7906 consecutive 99mTC-MDP bone scans performed over a 4-year period (January 2000 to May 2004) were also screened for the presence of PDB, and the prevalence of elevated alkaline phosphatase (ALP) levels (>300 UI/liter) was estimated from 7449 computerized medical records over a 3-year period (January 2000 to February 2003). The finding of PDB on the pelvic radiograph and bone scan was based on standardized radiological criteria. Results: At the end of the radiological surveys, 16/1778 pelvic PDB cases (8 males and 8 females) were observed in Siena and 41/6609 (27 males and 14 females) in Turin. The crude prevalence of the disease was 0.89{\%} in Siena and 0.62{\%} in Turin. Given that pelvic involvement is commonly described in 60-90{\%} of PDB patients, the estimated overall prevalence of PDB ranged from 1.0{\%} to 1.5{\%} in Siena and from 0.7{\%} to 1.0{\%} in Turin. No decrease in the prevalence of PDB was evident after comparison of prevalence rates from different periods. Biochemical analyses showed 296/7449 subjects with elevated ALP levels and normal liver enzymes, 87 of whom had confirmed diagnosis of PDB. The estimated prevalence of biochemical PDB was 1.5{\%}. The scintigraphic survey showed a PDB prevalence of 194/7906 (2.4{\%}), which was significantly higher than the radiological and biochemical estimates. Conclusions: Our surveys suggest that PDB in Italy has an estimated prevalence of at least 1{\%}, comparable with that observed in United States and other European countries, but lower than that described in Britain and New Zealand. No secular trend for a decreasing prevalence of PDB was observed.",
keywords = "Alkaline phosphatase, Bone scintigraphy, Epidemiology, Paget's disease of bone, Pelvic X-ray",
author = "Luigi Gennari and Stefano, {Marco Di} and Daniela Merlotti and Nicola Giordano and Giuseppe Martini and Cristina Tamone and Roberto Zatteri and {De Lucchi}, Roberto and Carlo Baldi and Angelo Vattimo and Silvia Capoccia and Luca Burroni and Simone Geraci and {De Paola}, Vincenzo and Anna Calabr{\`o} and Annalisa Avanzati and Giancarlo Isaia and Ranuccio Nuti",
year = "2005",
month = "10",
doi = "10.1359/JBMR.050518",
language = "English",
volume = "20",
pages = "1845--1850",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Prevalence of Paget's disease of bone in Italy

AU - Gennari, Luigi

AU - Stefano, Marco Di

AU - Merlotti, Daniela

AU - Giordano, Nicola

AU - Martini, Giuseppe

AU - Tamone, Cristina

AU - Zatteri, Roberto

AU - De Lucchi, Roberto

AU - Baldi, Carlo

AU - Vattimo, Angelo

AU - Capoccia, Silvia

AU - Burroni, Luca

AU - Geraci, Simone

AU - De Paola, Vincenzo

AU - Calabrò, Anna

AU - Avanzati, Annalisa

AU - Isaia, Giancarlo

AU - Nuti, Ranuccio

PY - 2005/10

Y1 - 2005/10

N2 - We examined the prevalence of PDB in Italy from radiological, scintigraphic, and biochemical surveys in two Italian towns. Prevalence rates varied from 0.7.% to 2.4%, were higher in males than in females, and slightly differed between the two towns. Unlike previous studies in populations of British descent, no secular trend for a decreasing prevalence emerged. Introduction: Clinical, radiological, and necropsy data from different countries suggested pronounced geographical variations in the prevalence of Paget's disease of bone (PDB). Despite the impact of the disease on the population, there are limited data on the prevalence of PDB in Italy. Materials and Methods: The objective of this study was to estimate the prevalence of PDB in the district of Siena (Central Italy) and Turin (Northern Italy) from radiological, biochemical, and scintigraphic surveys. We examined a sample of 1778 consecutive pelvic radiographs performed between 1999 and 2000 at the Hospital Radiology Unit in Siena and 6609 pelvic radiographs performed in 1986-1987, 1992-1993, and 1999-2002 from the Radiology Department of Molinette Hospital in Turin. In Siena, 7906 consecutive 99mTC-MDP bone scans performed over a 4-year period (January 2000 to May 2004) were also screened for the presence of PDB, and the prevalence of elevated alkaline phosphatase (ALP) levels (>300 UI/liter) was estimated from 7449 computerized medical records over a 3-year period (January 2000 to February 2003). The finding of PDB on the pelvic radiograph and bone scan was based on standardized radiological criteria. Results: At the end of the radiological surveys, 16/1778 pelvic PDB cases (8 males and 8 females) were observed in Siena and 41/6609 (27 males and 14 females) in Turin. The crude prevalence of the disease was 0.89% in Siena and 0.62% in Turin. Given that pelvic involvement is commonly described in 60-90% of PDB patients, the estimated overall prevalence of PDB ranged from 1.0% to 1.5% in Siena and from 0.7% to 1.0% in Turin. No decrease in the prevalence of PDB was evident after comparison of prevalence rates from different periods. Biochemical analyses showed 296/7449 subjects with elevated ALP levels and normal liver enzymes, 87 of whom had confirmed diagnosis of PDB. The estimated prevalence of biochemical PDB was 1.5%. The scintigraphic survey showed a PDB prevalence of 194/7906 (2.4%), which was significantly higher than the radiological and biochemical estimates. Conclusions: Our surveys suggest that PDB in Italy has an estimated prevalence of at least 1%, comparable with that observed in United States and other European countries, but lower than that described in Britain and New Zealand. No secular trend for a decreasing prevalence of PDB was observed.

AB - We examined the prevalence of PDB in Italy from radiological, scintigraphic, and biochemical surveys in two Italian towns. Prevalence rates varied from 0.7.% to 2.4%, were higher in males than in females, and slightly differed between the two towns. Unlike previous studies in populations of British descent, no secular trend for a decreasing prevalence emerged. Introduction: Clinical, radiological, and necropsy data from different countries suggested pronounced geographical variations in the prevalence of Paget's disease of bone (PDB). Despite the impact of the disease on the population, there are limited data on the prevalence of PDB in Italy. Materials and Methods: The objective of this study was to estimate the prevalence of PDB in the district of Siena (Central Italy) and Turin (Northern Italy) from radiological, biochemical, and scintigraphic surveys. We examined a sample of 1778 consecutive pelvic radiographs performed between 1999 and 2000 at the Hospital Radiology Unit in Siena and 6609 pelvic radiographs performed in 1986-1987, 1992-1993, and 1999-2002 from the Radiology Department of Molinette Hospital in Turin. In Siena, 7906 consecutive 99mTC-MDP bone scans performed over a 4-year period (January 2000 to May 2004) were also screened for the presence of PDB, and the prevalence of elevated alkaline phosphatase (ALP) levels (>300 UI/liter) was estimated from 7449 computerized medical records over a 3-year period (January 2000 to February 2003). The finding of PDB on the pelvic radiograph and bone scan was based on standardized radiological criteria. Results: At the end of the radiological surveys, 16/1778 pelvic PDB cases (8 males and 8 females) were observed in Siena and 41/6609 (27 males and 14 females) in Turin. The crude prevalence of the disease was 0.89% in Siena and 0.62% in Turin. Given that pelvic involvement is commonly described in 60-90% of PDB patients, the estimated overall prevalence of PDB ranged from 1.0% to 1.5% in Siena and from 0.7% to 1.0% in Turin. No decrease in the prevalence of PDB was evident after comparison of prevalence rates from different periods. Biochemical analyses showed 296/7449 subjects with elevated ALP levels and normal liver enzymes, 87 of whom had confirmed diagnosis of PDB. The estimated prevalence of biochemical PDB was 1.5%. The scintigraphic survey showed a PDB prevalence of 194/7906 (2.4%), which was significantly higher than the radiological and biochemical estimates. Conclusions: Our surveys suggest that PDB in Italy has an estimated prevalence of at least 1%, comparable with that observed in United States and other European countries, but lower than that described in Britain and New Zealand. No secular trend for a decreasing prevalence of PDB was observed.

KW - Alkaline phosphatase

KW - Bone scintigraphy

KW - Epidemiology

KW - Paget's disease of bone

KW - Pelvic X-ray

UR - http://www.scopus.com/inward/record.url?scp=25444484930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444484930&partnerID=8YFLogxK

U2 - 10.1359/JBMR.050518

DO - 10.1359/JBMR.050518

M3 - Article

C2 - 16160742

AN - SCOPUS:25444484930

VL - 20

SP - 1845

EP - 1850

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 10

ER -