Prevalence of papillomavirus, Epstein-Barr virus, cytomegalovirus, and herpes simplex virus type 2 in urinary bladder cancer

Paola Gazzaniga, Roberta Vercillo, Angela Gradilone, Ida Silvestri, Orietta Gandini, Maria Napolitano, Laura Giuliani, Alessandro Fioravanti, Michele Gallucci, Anna Maria Aglianò

Research output: Contribution to journalArticlepeer-review

Abstract

Recent epidemiological studies suggest that the risk for urological malignancies may be related to the exposure to infectious agents. Human Papillomaviruses type 16 and 18 (HPV 16, HPV 18), Epstein-Barr virus (EBV), cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV-2) have been suggested previously as cofactors in the pathogenesis of some malignancies in humans. The present paper, the presence of HPV 16, HPV 18, EBV, CMV and HSV-2 genomes was investigated in a panel of 35 biopsies from urinary bladder carcinomas using the polymerase chain reaction (PCR). Sequences of EBV, HPV, CMV and HSV-2 genomes were detected in 34%, 31%, 11% and 9% of tissue samples respectively, while in 20% of patients we found more than one viral infection. absence of viral genomes was found in normal bladder. To ourknowledge, this is the first report concerning the association of EBV, CMV and HSV-2 with bladder cancer. This finding may raise the question whether such viral infection may contribute to development and progression of some types of urological malignancies in humans.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalJournal of Medical Virology
Volume55
Issue number4
DOIs
Publication statusPublished - Aug 1998

Keywords

  • Bladder cancer
  • CMV
  • EBV
  • HPV
  • HSV-2
  • PCR

ASJC Scopus subject areas

  • Virology

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