Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals

Paul Gallagher, Pierre Olivier Lang, Antonio Cherubini, Eva Topinková, Alfonso Cruz-Jentoft, Beatriz Montero Errasquín, Pavla Mádlová, Beatrice Gasperini, Hilde Baeyens, Jean Pierre Baeyens, Jean Pierre Michel, Denis O'Mahony

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Abstract

Purpose: Potentially inappropriate prescribing is common in older people presenting to hospital with acute illness in Ireland. The aim of this study was to determine if this phenomenon is unique to Ireland or whether it is a more widespread problem in hospitals across Europe. Methods: Prospective data were collected from 900 consecutive older patients admitted to six university teaching hospitals (150 patients per centre) in Geneva (Switzerland), Madrid (Spain), Oostende (Belgium), Perugia (Italy), Prague (Czech Republic) and Cork (Ireland). Age, gender, comorbidity, cognitive status, prescription medicines taken before admission and baseline haematological, biochemical and electrocardiographic data were recorded. STOPP and Beers' criteria were applied to detect potentially inappropriate medicines (PIMs). START criteria were applied to detect potentially inappropriate prescribing omissions (PPOs). Results: The overall PIM prevalence rate was 51.3% using STOPP criteria, varying from 34.7% in Prague to 77.3% in Geneva, and 30.4% using Beer's criteria, varying from 22.7% in Prague to 43.3% in Geneva. Using START criteria, the overall PPO prevalence rate was 59.4%, ranging from 51.3% in Cork to 72.7% in Perugia. Polypharmacy predicted the presence of PIMs using STOPP criteria [with∈>10 medications: odds ratio (OR)∈∈7.22, 95% confidence interval (CI) 4.30-12.12, p∈10 medications: OR∈4.87, 95% CI 3.00-7.90, p∈

Original languageEnglish
Pages (from-to)1175-1188
Number of pages14
JournalEuropean Journal of Clinical Pharmacology
Volume67
Issue number11
DOIs
Publication statusPublished - Nov 2011

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Keywords

  • Beers' criteria
  • Elderly
  • Inappropriate prescribing
  • STOPP/START

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Gallagher, P., Lang, P. O., Cherubini, A., Topinková, E., Cruz-Jentoft, A., Montero Errasquín, B., Mádlová, P., Gasperini, B., Baeyens, H., Baeyens, J. P., Michel, J. P., & O'Mahony, D. (2011). Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. European Journal of Clinical Pharmacology, 67(11), 1175-1188. https://doi.org/10.1007/s00228-011-1061-0