Prevalence of primary cutis verticis gyrata in a psychiatric population: Association with chromosomal fragile sites

C. Schepis, R. Palazzo, S. P. Cannavo, R. M. Ragusa, C. Barletta, E. Spina

Research output: Contribution to journalArticle

Abstract

The prevalence of cutis verticis gyrata was studied in a psychiatric institutional population of 494 patients, the majority of whom were mentally retarded or had chronic schizophrenia. Twenty-two subjects (21 males and 1 female) were found to have primary cutis verticis gyrata, yielding a prevalence of about 4.5%. The frequency of the scalp disorder was 11.4% among mentally retarded patients and 1.7% in schizophrenic subjects. A cytogenetic study was performed on patients with primary cutis verticis gyrata. In 9 out of 21 subjects there was evidence of chromosomal fragile sites: 5 patients had fragile sites on the X-chromosome, in 2 there was fragility of chromosome 12 and in 2, fragility of chromosome 9. The fragile X-site is the genetic marker of the 'fragile X-syndrome', a sex-linked inherited disorder often associated with mental retardation and other neuropathological findings.

Original languageEnglish
Pages (from-to)483-486
Number of pages4
JournalActa Dermato-Venereologica
Volume70
Issue number6
Publication statusPublished - 1990

Fingerprint

Psychiatry
Fragile X Syndrome
Mentally Disabled Persons
Population
schizophrenia
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 2
X Chromosome
Scalp
Genetic Markers
Cytogenetics
Intellectual Disability
Schizophrenia
evidence
Chromosome

Keywords

  • fragile X-syndrome
  • mental retardation
  • schizophrenia

ASJC Scopus subject areas

  • Dermatology

Cite this

Prevalence of primary cutis verticis gyrata in a psychiatric population : Association with chromosomal fragile sites. / Schepis, C.; Palazzo, R.; Cannavo, S. P.; Ragusa, R. M.; Barletta, C.; Spina, E.

In: Acta Dermato-Venereologica, Vol. 70, No. 6, 1990, p. 483-486.

Research output: Contribution to journalArticle

Schepis, C, Palazzo, R, Cannavo, SP, Ragusa, RM, Barletta, C & Spina, E 1990, 'Prevalence of primary cutis verticis gyrata in a psychiatric population: Association with chromosomal fragile sites', Acta Dermato-Venereologica, vol. 70, no. 6, pp. 483-486.
Schepis, C. ; Palazzo, R. ; Cannavo, S. P. ; Ragusa, R. M. ; Barletta, C. ; Spina, E. / Prevalence of primary cutis verticis gyrata in a psychiatric population : Association with chromosomal fragile sites. In: Acta Dermato-Venereologica. 1990 ; Vol. 70, No. 6. pp. 483-486.
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