Prevalence of Primary HPV in Djibouti: Feasibility of Screening for Early Diagnosis of Squamous Intraepithelial Lesions

Alessio Petrelli, Anteo Di Napoli, Paolo Giorgi Rossi, Alessandra Rossi, Daniele Luccini, Ilaria Di Marco, Amadou Laico Traoré, Anna Gillio Tos, Morena Trevisan, Concetta Mirisola, Gianfranco Costanzo

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Abstract

OBJECTIVE: In many African Sub-Saharan countries, human papilloma virus (HPV) prevalence data are not available. The current study estimated the prevalence of HPV virus in the female population of Djibouti. METHODS: Approximately 1000 asymptomatic women 16 to 64 years old were enrolled from 3 of the main health structures of Djibouti in 2014 and 2015; 998 cervical samples were tested for HPV-DNA of high risk types, 499 during the first year, and 499 during the second. Positive samples were typed with an HPV genotyping kit. RESULTS: The women were an average age of 38.8 years (SD, 10.2); 54 women tested positive for HPV (prevalence rate, 5.4% [95% confidence interval, 4.0–6.8]). The highest prevalence was observed among the women younger than 35 years. HPV66 was the most prevalent (15.4% of the infections), followed by HPV31 and HPV52 (10.8% both) and HPV16 (9.2%). All 54 women who tested HPV-positive underwent a Pap test, which was positive in 8 cases (14.8%): 2 high-grade squamous intraepithelial lesion (HSIL) and 6 low-grade (LSIL). CONCLUSIONS: The HPV prevalence shows a curve by age similar to that of other African countries. The proportion of HPV16 is among the lowest ever seen in similar studies. The findings suggest to Djibouti the choice of a strategy of screening that includes forms of cytological triage, thus limiting recourse to colposcopy.

Original languageEnglish
Pages (from-to)321-6
Number of pages6
JournalJournal of Lower Genital Tract Disease
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 27 2016

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Papillomaviridae
Djibouti
Early Diagnosis
Papanicolaou Test
Colposcopy
Triage
Squamous Intraepithelial Lesions of the Cervix
Cross-Sectional Studies
Confidence Intervals
Viruses

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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Prevalence of Primary HPV in Djibouti : Feasibility of Screening for Early Diagnosis of Squamous Intraepithelial Lesions. / Petrelli, Alessio; Di Napoli, Anteo; Giorgi Rossi, Paolo; Rossi, Alessandra; Luccini, Daniele; Di Marco, Ilaria; Traoré, Amadou Laico; Gillio Tos, Anna; Trevisan, Morena; Mirisola, Concetta; Costanzo, Gianfranco.

In: Journal of Lower Genital Tract Disease, Vol. 20, No. 4, 27.10.2016, p. 321-6.

Research output: Contribution to journalArticle

Petrelli, A, Di Napoli, A, Giorgi Rossi, P, Rossi, A, Luccini, D, Di Marco, I, Traoré, AL, Gillio Tos, A, Trevisan, M, Mirisola, C & Costanzo, G 2016, 'Prevalence of Primary HPV in Djibouti: Feasibility of Screening for Early Diagnosis of Squamous Intraepithelial Lesions', Journal of Lower Genital Tract Disease, vol. 20, no. 4, pp. 321-6. https://doi.org/10.1097/LGT.0000000000000240
Petrelli, Alessio ; Di Napoli, Anteo ; Giorgi Rossi, Paolo ; Rossi, Alessandra ; Luccini, Daniele ; Di Marco, Ilaria ; Traoré, Amadou Laico ; Gillio Tos, Anna ; Trevisan, Morena ; Mirisola, Concetta ; Costanzo, Gianfranco. / Prevalence of Primary HPV in Djibouti : Feasibility of Screening for Early Diagnosis of Squamous Intraepithelial Lesions. In: Journal of Lower Genital Tract Disease. 2016 ; Vol. 20, No. 4. pp. 321-6.
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AU - Di Napoli, Anteo

AU - Giorgi Rossi, Paolo

AU - Rossi, Alessandra

AU - Luccini, Daniele

AU - Di Marco, Ilaria

AU - Traoré, Amadou Laico

AU - Gillio Tos, Anna

AU - Trevisan, Morena

AU - Mirisola, Concetta

AU - Costanzo, Gianfranco

PY - 2016/10/27

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N2 - OBJECTIVE: In many African Sub-Saharan countries, human papilloma virus (HPV) prevalence data are not available. The current study estimated the prevalence of HPV virus in the female population of Djibouti. METHODS: Approximately 1000 asymptomatic women 16 to 64 years old were enrolled from 3 of the main health structures of Djibouti in 2014 and 2015; 998 cervical samples were tested for HPV-DNA of high risk types, 499 during the first year, and 499 during the second. Positive samples were typed with an HPV genotyping kit. RESULTS: The women were an average age of 38.8 years (SD, 10.2); 54 women tested positive for HPV (prevalence rate, 5.4% [95% confidence interval, 4.0–6.8]). The highest prevalence was observed among the women younger than 35 years. HPV66 was the most prevalent (15.4% of the infections), followed by HPV31 and HPV52 (10.8% both) and HPV16 (9.2%). All 54 women who tested HPV-positive underwent a Pap test, which was positive in 8 cases (14.8%): 2 high-grade squamous intraepithelial lesion (HSIL) and 6 low-grade (LSIL). CONCLUSIONS: The HPV prevalence shows a curve by age similar to that of other African countries. The proportion of HPV16 is among the lowest ever seen in similar studies. The findings suggest to Djibouti the choice of a strategy of screening that includes forms of cytological triage, thus limiting recourse to colposcopy.

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