Prevalence of resistance to anti-tuberculosis drugs

Results of the 1998/99 national survey in Italy

Giovanni Battista Migliori, L. Fattorini, R. Vaccarino, G. Besozzi, C. Saltini, G. Orefici, E. Iona, A. Matteelli, F. Fiorentini, L. R. Codecasa, L. Casali, A. Cassone, A. De Santis, V. Giorgio, P. Vinciguerra, G. Angarano, L. Petrozzi, D. Costa, F. Gozzellino, A. Perboni & 79 others D. Marchetti, A. Pascali, F. Falcone, V. Mariano, F. Rizza, P. Pretto, A. Turano, A. Matteelli, G. P. Carosi, A. G. Farris, G. P. Ligia, G. Orani, B. Farris, C. Foschi, G. Trucco, S. Aiolfi, T. Ceruti, M. Parpanesi, S. Calabro, G. Felisatti, E. Tortoli, S. Nutini, G. Montini, V. D'Ambrosio, A. Ceraminiello, S. Bernorio, L. Buono, P. Montesano, E. Vinci, E. Sabato, S. Gamba, P. Crepaldi, E. Magliano, V. Penati, P. Vaccarino, A. Astolfi, G. Bertoli, F. Rupianesi, M. Losi, L. Richeldi, G. Ferrara, E. Minuccio, G. Napolitano, G. L. Molinari, L. Saini, A. Garzone, C. Vertuccio, S. Marcias, M. Menozzi, P. Marone, V. Peona, C. Nascimbene, A. Pasi, A. Cascina, A. Monaco, O. Penza, M. B. Pasticci, F. Bistoni, T. Sposini, V. Colorizio, M. Confalonieri, P. Bottrighi, G. Macor, G. Moretti, R. Fatigante, A. Barbaro, G. Agati, F. Zaccara, S. Viola, R. Le Donne, G. Farinelli, D. Mancini, M. Ermeti, R. Longi, C. Saltini, M. Tronci, A. Bisetti, A. Altieri, G. Fadda

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: To determine the prevalence of resistance to the main anti-tuberculosis drugs in newly and previously treated tuberculosis patients in Italy and to evaluate the contribution of foreign-born and human immunodeficiency virus (HIV) positive cases to drug resistance. METHODS: Methods and definitions were derived from the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance. Univariate and multivariate analysis was used to study prevalence rates of drug resistance in risk groups. RESULTS: In a national survey in Italy, 810 initial isolates of Mycobacterium tuberculosis (683 from new cases, 115 from retreatment cases and 12 from patients whose treatment history was unknown/dubious) were analysed. Low prevalence of drug and multidrug resistance was found in the new cases (isoniazid 2.9%; rifampicin 0.8%; multidrug resistance 1.2%; any drug resistance 12.3%). The prevalence of resistance to isoniazid and rifampicin was significantly higher in immigrants and HIV-positive subjects, respectively. A high prevalence of drug resistance was found in cases with previous treatment failure or default (isoniazid 5.2%; rifampidn 4.3%; multidrug resistance 36.5%; any drug resistance 61.7%). RECOMMENDATIONS: Special efforts are necessary to monitor trends in drug resistance and to ensure favourable treatment outcomes among immigrants and HIV-positive tuberculosis cases.

Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume6
Issue number1
Publication statusPublished - 2002

Fingerprint

Drug Resistance
Italy
Tuberculosis
Pharmaceutical Preparations
Isoniazid
Multiple Drug Resistance
HIV
Rifampin
Retreatment
Surveys and Questionnaires
Treatment Failure
Mycobacterium tuberculosis
Multivariate Analysis
Cross-Sectional Studies
History

Keywords

  • Drug susceptibility testing
  • HIV
  • Immigrant
  • Prevalence of resistance
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Prevalence of resistance to anti-tuberculosis drugs : Results of the 1998/99 national survey in Italy. / Migliori, Giovanni Battista; Fattorini, L.; Vaccarino, R.; Besozzi, G.; Saltini, C.; Orefici, G.; Iona, E.; Matteelli, A.; Fiorentini, F.; Codecasa, L. R.; Casali, L.; Cassone, A.; De Santis, A.; Giorgio, V.; Vinciguerra, P.; Angarano, G.; Petrozzi, L.; Costa, D.; Gozzellino, F.; Perboni, A.; Marchetti, D.; Pascali, A.; Falcone, F.; Mariano, V.; Rizza, F.; Pretto, P.; Turano, A.; Matteelli, A.; Carosi, G. P.; Farris, A. G.; Ligia, G. P.; Orani, G.; Farris, B.; Foschi, C.; Trucco, G.; Aiolfi, S.; Ceruti, T.; Parpanesi, M.; Calabro, S.; Felisatti, G.; Tortoli, E.; Nutini, S.; Montini, G.; D'Ambrosio, V.; Ceraminiello, A.; Bernorio, S.; Buono, L.; Montesano, P.; Vinci, E.; Sabato, E.; Gamba, S.; Crepaldi, P.; Magliano, E.; Penati, V.; Vaccarino, P.; Astolfi, A.; Bertoli, G.; Rupianesi, F.; Losi, M.; Richeldi, L.; Ferrara, G.; Minuccio, E.; Napolitano, G.; Molinari, G. L.; Saini, L.; Garzone, A.; Vertuccio, C.; Marcias, S.; Menozzi, M.; Marone, P.; Peona, V.; Nascimbene, C.; Pasi, A.; Cascina, A.; Monaco, A.; Penza, O.; Pasticci, M. B.; Bistoni, F.; Sposini, T.; Colorizio, V.; Confalonieri, M.; Bottrighi, P.; Macor, G.; Moretti, G.; Fatigante, R.; Barbaro, A.; Agati, G.; Zaccara, F.; Viola, S.; Le Donne, R.; Farinelli, G.; Mancini, D.; Ermeti, M.; Longi, R.; Saltini, C.; Tronci, M.; Bisetti, A.; Altieri, A.; Fadda, G.

In: International Journal of Tuberculosis and Lung Disease, Vol. 6, No. 1, 2002, p. 32-38.

Research output: Contribution to journalArticle

Migliori, GB, Fattorini, L, Vaccarino, R, Besozzi, G, Saltini, C, Orefici, G, Iona, E, Matteelli, A, Fiorentini, F, Codecasa, LR, Casali, L, Cassone, A, De Santis, A, Giorgio, V, Vinciguerra, P, Angarano, G, Petrozzi, L, Costa, D, Gozzellino, F, Perboni, A, Marchetti, D, Pascali, A, Falcone, F, Mariano, V, Rizza, F, Pretto, P, Turano, A, Matteelli, A, Carosi, GP, Farris, AG, Ligia, GP, Orani, G, Farris, B, Foschi, C, Trucco, G, Aiolfi, S, Ceruti, T, Parpanesi, M, Calabro, S, Felisatti, G, Tortoli, E, Nutini, S, Montini, G, D'Ambrosio, V, Ceraminiello, A, Bernorio, S, Buono, L, Montesano, P, Vinci, E, Sabato, E, Gamba, S, Crepaldi, P, Magliano, E, Penati, V, Vaccarino, P, Astolfi, A, Bertoli, G, Rupianesi, F, Losi, M, Richeldi, L, Ferrara, G, Minuccio, E, Napolitano, G, Molinari, GL, Saini, L, Garzone, A, Vertuccio, C, Marcias, S, Menozzi, M, Marone, P, Peona, V, Nascimbene, C, Pasi, A, Cascina, A, Monaco, A, Penza, O, Pasticci, MB, Bistoni, F, Sposini, T, Colorizio, V, Confalonieri, M, Bottrighi, P, Macor, G, Moretti, G, Fatigante, R, Barbaro, A, Agati, G, Zaccara, F, Viola, S, Le Donne, R, Farinelli, G, Mancini, D, Ermeti, M, Longi, R, Saltini, C, Tronci, M, Bisetti, A, Altieri, A & Fadda, G 2002, 'Prevalence of resistance to anti-tuberculosis drugs: Results of the 1998/99 national survey in Italy', International Journal of Tuberculosis and Lung Disease, vol. 6, no. 1, pp. 32-38.
Migliori, Giovanni Battista ; Fattorini, L. ; Vaccarino, R. ; Besozzi, G. ; Saltini, C. ; Orefici, G. ; Iona, E. ; Matteelli, A. ; Fiorentini, F. ; Codecasa, L. R. ; Casali, L. ; Cassone, A. ; De Santis, A. ; Giorgio, V. ; Vinciguerra, P. ; Angarano, G. ; Petrozzi, L. ; Costa, D. ; Gozzellino, F. ; Perboni, A. ; Marchetti, D. ; Pascali, A. ; Falcone, F. ; Mariano, V. ; Rizza, F. ; Pretto, P. ; Turano, A. ; Matteelli, A. ; Carosi, G. P. ; Farris, A. G. ; Ligia, G. P. ; Orani, G. ; Farris, B. ; Foschi, C. ; Trucco, G. ; Aiolfi, S. ; Ceruti, T. ; Parpanesi, M. ; Calabro, S. ; Felisatti, G. ; Tortoli, E. ; Nutini, S. ; Montini, G. ; D'Ambrosio, V. ; Ceraminiello, A. ; Bernorio, S. ; Buono, L. ; Montesano, P. ; Vinci, E. ; Sabato, E. ; Gamba, S. ; Crepaldi, P. ; Magliano, E. ; Penati, V. ; Vaccarino, P. ; Astolfi, A. ; Bertoli, G. ; Rupianesi, F. ; Losi, M. ; Richeldi, L. ; Ferrara, G. ; Minuccio, E. ; Napolitano, G. ; Molinari, G. L. ; Saini, L. ; Garzone, A. ; Vertuccio, C. ; Marcias, S. ; Menozzi, M. ; Marone, P. ; Peona, V. ; Nascimbene, C. ; Pasi, A. ; Cascina, A. ; Monaco, A. ; Penza, O. ; Pasticci, M. B. ; Bistoni, F. ; Sposini, T. ; Colorizio, V. ; Confalonieri, M. ; Bottrighi, P. ; Macor, G. ; Moretti, G. ; Fatigante, R. ; Barbaro, A. ; Agati, G. ; Zaccara, F. ; Viola, S. ; Le Donne, R. ; Farinelli, G. ; Mancini, D. ; Ermeti, M. ; Longi, R. ; Saltini, C. ; Tronci, M. ; Bisetti, A. ; Altieri, A. ; Fadda, G. / Prevalence of resistance to anti-tuberculosis drugs : Results of the 1998/99 national survey in Italy. In: International Journal of Tuberculosis and Lung Disease. 2002 ; Vol. 6, No. 1. pp. 32-38.
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abstract = "OBJECTIVE: To determine the prevalence of resistance to the main anti-tuberculosis drugs in newly and previously treated tuberculosis patients in Italy and to evaluate the contribution of foreign-born and human immunodeficiency virus (HIV) positive cases to drug resistance. METHODS: Methods and definitions were derived from the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance. Univariate and multivariate analysis was used to study prevalence rates of drug resistance in risk groups. RESULTS: In a national survey in Italy, 810 initial isolates of Mycobacterium tuberculosis (683 from new cases, 115 from retreatment cases and 12 from patients whose treatment history was unknown/dubious) were analysed. Low prevalence of drug and multidrug resistance was found in the new cases (isoniazid 2.9{\%}; rifampicin 0.8{\%}; multidrug resistance 1.2{\%}; any drug resistance 12.3{\%}). The prevalence of resistance to isoniazid and rifampicin was significantly higher in immigrants and HIV-positive subjects, respectively. A high prevalence of drug resistance was found in cases with previous treatment failure or default (isoniazid 5.2{\%}; rifampidn 4.3{\%}; multidrug resistance 36.5{\%}; any drug resistance 61.7{\%}). RECOMMENDATIONS: Special efforts are necessary to monitor trends in drug resistance and to ensure favourable treatment outcomes among immigrants and HIV-positive tuberculosis cases.",
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TY - JOUR

T1 - Prevalence of resistance to anti-tuberculosis drugs

T2 - Results of the 1998/99 national survey in Italy

AU - Migliori, Giovanni Battista

AU - Fattorini, L.

AU - Vaccarino, R.

AU - Besozzi, G.

AU - Saltini, C.

AU - Orefici, G.

AU - Iona, E.

AU - Matteelli, A.

AU - Fiorentini, F.

AU - Codecasa, L. R.

AU - Casali, L.

AU - Cassone, A.

AU - De Santis, A.

AU - Giorgio, V.

AU - Vinciguerra, P.

AU - Angarano, G.

AU - Petrozzi, L.

AU - Costa, D.

AU - Gozzellino, F.

AU - Perboni, A.

AU - Marchetti, D.

AU - Pascali, A.

AU - Falcone, F.

AU - Mariano, V.

AU - Rizza, F.

AU - Pretto, P.

AU - Turano, A.

AU - Matteelli, A.

AU - Carosi, G. P.

AU - Farris, A. G.

AU - Ligia, G. P.

AU - Orani, G.

AU - Farris, B.

AU - Foschi, C.

AU - Trucco, G.

AU - Aiolfi, S.

AU - Ceruti, T.

AU - Parpanesi, M.

AU - Calabro, S.

AU - Felisatti, G.

AU - Tortoli, E.

AU - Nutini, S.

AU - Montini, G.

AU - D'Ambrosio, V.

AU - Ceraminiello, A.

AU - Bernorio, S.

AU - Buono, L.

AU - Montesano, P.

AU - Vinci, E.

AU - Sabato, E.

AU - Gamba, S.

AU - Crepaldi, P.

AU - Magliano, E.

AU - Penati, V.

AU - Vaccarino, P.

AU - Astolfi, A.

AU - Bertoli, G.

AU - Rupianesi, F.

AU - Losi, M.

AU - Richeldi, L.

AU - Ferrara, G.

AU - Minuccio, E.

AU - Napolitano, G.

AU - Molinari, G. L.

AU - Saini, L.

AU - Garzone, A.

AU - Vertuccio, C.

AU - Marcias, S.

AU - Menozzi, M.

AU - Marone, P.

AU - Peona, V.

AU - Nascimbene, C.

AU - Pasi, A.

AU - Cascina, A.

AU - Monaco, A.

AU - Penza, O.

AU - Pasticci, M. B.

AU - Bistoni, F.

AU - Sposini, T.

AU - Colorizio, V.

AU - Confalonieri, M.

AU - Bottrighi, P.

AU - Macor, G.

AU - Moretti, G.

AU - Fatigante, R.

AU - Barbaro, A.

AU - Agati, G.

AU - Zaccara, F.

AU - Viola, S.

AU - Le Donne, R.

AU - Farinelli, G.

AU - Mancini, D.

AU - Ermeti, M.

AU - Longi, R.

AU - Saltini, C.

AU - Tronci, M.

AU - Bisetti, A.

AU - Altieri, A.

AU - Fadda, G.

PY - 2002

Y1 - 2002

N2 - OBJECTIVE: To determine the prevalence of resistance to the main anti-tuberculosis drugs in newly and previously treated tuberculosis patients in Italy and to evaluate the contribution of foreign-born and human immunodeficiency virus (HIV) positive cases to drug resistance. METHODS: Methods and definitions were derived from the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance. Univariate and multivariate analysis was used to study prevalence rates of drug resistance in risk groups. RESULTS: In a national survey in Italy, 810 initial isolates of Mycobacterium tuberculosis (683 from new cases, 115 from retreatment cases and 12 from patients whose treatment history was unknown/dubious) were analysed. Low prevalence of drug and multidrug resistance was found in the new cases (isoniazid 2.9%; rifampicin 0.8%; multidrug resistance 1.2%; any drug resistance 12.3%). The prevalence of resistance to isoniazid and rifampicin was significantly higher in immigrants and HIV-positive subjects, respectively. A high prevalence of drug resistance was found in cases with previous treatment failure or default (isoniazid 5.2%; rifampidn 4.3%; multidrug resistance 36.5%; any drug resistance 61.7%). RECOMMENDATIONS: Special efforts are necessary to monitor trends in drug resistance and to ensure favourable treatment outcomes among immigrants and HIV-positive tuberculosis cases.

AB - OBJECTIVE: To determine the prevalence of resistance to the main anti-tuberculosis drugs in newly and previously treated tuberculosis patients in Italy and to evaluate the contribution of foreign-born and human immunodeficiency virus (HIV) positive cases to drug resistance. METHODS: Methods and definitions were derived from the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance. Univariate and multivariate analysis was used to study prevalence rates of drug resistance in risk groups. RESULTS: In a national survey in Italy, 810 initial isolates of Mycobacterium tuberculosis (683 from new cases, 115 from retreatment cases and 12 from patients whose treatment history was unknown/dubious) were analysed. Low prevalence of drug and multidrug resistance was found in the new cases (isoniazid 2.9%; rifampicin 0.8%; multidrug resistance 1.2%; any drug resistance 12.3%). The prevalence of resistance to isoniazid and rifampicin was significantly higher in immigrants and HIV-positive subjects, respectively. A high prevalence of drug resistance was found in cases with previous treatment failure or default (isoniazid 5.2%; rifampidn 4.3%; multidrug resistance 36.5%; any drug resistance 61.7%). RECOMMENDATIONS: Special efforts are necessary to monitor trends in drug resistance and to ensure favourable treatment outcomes among immigrants and HIV-positive tuberculosis cases.

KW - Drug susceptibility testing

KW - HIV

KW - Immigrant

KW - Prevalence of resistance

KW - Tuberculosis

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M3 - Article

VL - 6

SP - 32

EP - 38

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

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