Prevalence of sinonasal disease in children with juvenile idiopathic arthritis

Carlotta Pipolo, Federica Turati, Paolo Cressoni, Giampietro Farronato, Francesca Angiero, Umberto Garagiola, Daniele Di Pasquale, Alberto M. Saibene, Riccardo Lenzi, Giovanni Felisati

Research output: Contribution to journalArticlepeer-review


Objectives/Hypothesis: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and is caused by a multitude of well-studied disorders. However, the association between JIA and/or its treatment and sinonasal inflammatory disease (SNID) has never been studied. We therefore investigated this relationship to gain more insight into burdening pathologies connected to JIA. Study Design: Retrospective evaluation. Methods: A retrospective evaluation according to the Lund-Mackay score of cone-beam computed tomography scans (CBCT) performed in 70 children affected by JIA and compared to CBCT scans of 124 healthy controls was conducted. The prevalence of sinonasal opacification and adenoid hypertrophy in patients affected with JIA was compared with findings obtained in unaffected children. Results: JIA was significantly associated with SNID (P = .030). Of patients with JIA, 18.6% had SNID, whereas in children without JIA, only 8.1% had SNID. The odds ratio values were 5.38 (95% confidence interval [CI]: 1.90-15.26) for treated and 0.92 (95% CI: 0.18-4.83) for untreated JIA. No clear difference was found depending on the duration of JIA. No association was found between adenoid hypertrophy and SNID (P = .816). Conclusions: Our data suggest that JIA patients, especially when undergoing immunosuppressive therapy, should be subjected to an ear, nose, and throat evaluation. A prospective study including clinical evaluation would be of the utmost importance to provide evidence on which to base comprehensive healthcare for these patients.

Original languageEnglish
Pages (from-to)291-295
Number of pages5
Issue number2
Publication statusPublished - Feb 1 2015


  • Adenoid hypertrophy
  • Cone beam computed tomography
  • Juvenile idiopathic arthritis
  • Lund-Mackay score
  • Sinonasal disease
  • Sinusitis

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)


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