Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus

Aurora Parodi, Emanuele Cozzani, Cesare Massone, Alfredo Rebora, Luigi Priano, Giovanni Ghigliotti, Paolo Balbi, Franco Rongioletti, Claudia Micalizzi, Rossella Cestari, Giuseppe Varaldo, Gianfranco Barabino, Giuseppe Cannata, Francesco Drago, Vittorio Moreno, Luciano Schiazza, Gianfranco Muzio, Enrico Scaparro, Bruno Alibrandi, Roberto BandelloniMarina Ciaccio, Giovanni Desirello, Pier Mario Isola, Stefano Ottoboni, Paolo Rampini, Giuseppe Santoro, Stefania Sorbara, Giovanni Virno

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. These antibodies are directed against a 70-kd antigen. Objective: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus. Patients and methods: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen. Results: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd. Limitations: This is a serological study; results from direct immunofluorescence studies would be interesting. Conclusion: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus.

Original languageEnglish
Pages (from-to)974-978
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume56
Issue number6
DOIs
Publication statusPublished - Jun 2007

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Lichen Planus
Antinuclear Antibodies
Epithelium
Indirect Fluorescent Antibody Technique
Antibodies
Antigens
Necrotizing Ulcerative Gingivitis
Esophagus
Haplorhini
Direct Fluorescent Antibody Technique
Keratinocytes
Immunoblotting

ASJC Scopus subject areas

  • Dermatology

Cite this

Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus. / Parodi, Aurora; Cozzani, Emanuele; Massone, Cesare; Rebora, Alfredo; Priano, Luigi; Ghigliotti, Giovanni; Balbi, Paolo; Rongioletti, Franco; Micalizzi, Claudia; Cestari, Rossella; Varaldo, Giuseppe; Barabino, Gianfranco; Cannata, Giuseppe; Drago, Francesco; Moreno, Vittorio; Schiazza, Luciano; Muzio, Gianfranco; Scaparro, Enrico; Alibrandi, Bruno; Bandelloni, Roberto; Ciaccio, Marina; Desirello, Giovanni; Isola, Pier Mario; Ottoboni, Stefano; Rampini, Paolo; Santoro, Giuseppe; Sorbara, Stefania; Virno, Giovanni.

In: Journal of the American Academy of Dermatology, Vol. 56, No. 6, 06.2007, p. 974-978.

Research output: Contribution to journalArticle

Parodi, A, Cozzani, E, Massone, C, Rebora, A, Priano, L, Ghigliotti, G, Balbi, P, Rongioletti, F, Micalizzi, C, Cestari, R, Varaldo, G, Barabino, G, Cannata, G, Drago, F, Moreno, V, Schiazza, L, Muzio, G, Scaparro, E, Alibrandi, B, Bandelloni, R, Ciaccio, M, Desirello, G, Isola, PM, Ottoboni, S, Rampini, P, Santoro, G, Sorbara, S & Virno, G 2007, 'Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus', Journal of the American Academy of Dermatology, vol. 56, no. 6, pp. 974-978. https://doi.org/10.1016/j.jaad.2005.10.033
Parodi, Aurora ; Cozzani, Emanuele ; Massone, Cesare ; Rebora, Alfredo ; Priano, Luigi ; Ghigliotti, Giovanni ; Balbi, Paolo ; Rongioletti, Franco ; Micalizzi, Claudia ; Cestari, Rossella ; Varaldo, Giuseppe ; Barabino, Gianfranco ; Cannata, Giuseppe ; Drago, Francesco ; Moreno, Vittorio ; Schiazza, Luciano ; Muzio, Gianfranco ; Scaparro, Enrico ; Alibrandi, Bruno ; Bandelloni, Roberto ; Ciaccio, Marina ; Desirello, Giovanni ; Isola, Pier Mario ; Ottoboni, Stefano ; Rampini, Paolo ; Santoro, Giuseppe ; Sorbara, Stefania ; Virno, Giovanni. / Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus. In: Journal of the American Academy of Dermatology. 2007 ; Vol. 56, No. 6. pp. 974-978.
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abstract = "Background: Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. These antibodies are directed against a 70-kd antigen. Objective: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus. Patients and methods: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen. Results: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd. Limitations: This is a serological study; results from direct immunofluorescence studies would be interesting. Conclusion: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus.",
author = "Aurora Parodi and Emanuele Cozzani and Cesare Massone and Alfredo Rebora and Luigi Priano and Giovanni Ghigliotti and Paolo Balbi and Franco Rongioletti and Claudia Micalizzi and Rossella Cestari and Giuseppe Varaldo and Gianfranco Barabino and Giuseppe Cannata and Francesco Drago and Vittorio Moreno and Luciano Schiazza and Gianfranco Muzio and Enrico Scaparro and Bruno Alibrandi and Roberto Bandelloni and Marina Ciaccio and Giovanni Desirello and Isola, {Pier Mario} and Stefano Ottoboni and Paolo Rampini and Giuseppe Santoro and Stefania Sorbara and Giovanni Virno",
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T1 - Prevalence of stratified epithelium-specific antinuclear antibodies in 138 patients with lichen planus

AU - Parodi, Aurora

AU - Cozzani, Emanuele

AU - Massone, Cesare

AU - Rebora, Alfredo

AU - Priano, Luigi

AU - Ghigliotti, Giovanni

AU - Balbi, Paolo

AU - Rongioletti, Franco

AU - Micalizzi, Claudia

AU - Cestari, Rossella

AU - Varaldo, Giuseppe

AU - Barabino, Gianfranco

AU - Cannata, Giuseppe

AU - Drago, Francesco

AU - Moreno, Vittorio

AU - Schiazza, Luciano

AU - Muzio, Gianfranco

AU - Scaparro, Enrico

AU - Alibrandi, Bruno

AU - Bandelloni, Roberto

AU - Ciaccio, Marina

AU - Desirello, Giovanni

AU - Isola, Pier Mario

AU - Ottoboni, Stefano

AU - Rampini, Paolo

AU - Santoro, Giuseppe

AU - Sorbara, Stefania

AU - Virno, Giovanni

PY - 2007/6

Y1 - 2007/6

N2 - Background: Antibodies to stratified epithelia characterize chronic ulcerative stomatitis, an entity that very closely resembles erosive lichen planus both clinically and histologically. These antibodies are directed against a 70-kd antigen. Objective: Our aim was to verify whether antibodies to stratified epithelia are present in patients with common lichen planus. Patients and methods: One hundred thirty-eight patients with various forms of lichen planus were studied. Indirect immunofluorescence was performed on both monkey esophagus and HEp2-2000 cells. Immunoblotting was done with cultured keratinocytes used as the source antigen. Results: Nineteen patients had antibodies to stratified epithelia (in 9 directed against an antigen of 70 kd). Forty-eight patients had circulating antibodies detected by indirect immunofluorescence on both monkey esophagus and HEp2-2000 cells (in 7 directed against an antigen of 70 kd). Indirect immunofluorescence was positive only on HEp2-2000 cells in 21 patients. Indirect immunofluorescence was negative in 50 patients on both HEp2-2000 cells and monkey esophagus. None of the last 71 patients had antibodies directed to an antigen of 70 kd. Limitations: This is a serological study; results from direct immunofluorescence studies would be interesting. Conclusion: Antibodies to stratified epithelia directed to an antigen of 70 kd are not exclusive to chronic ulcerative stomatitis, but are also present in some patients with lichen planus.

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