Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran

Ali Taher, Hussain Isma'eel, Ghassan Mehio, Daniela Bignamini, Antonis Kattamis, Eliezer A. Rachmilewitz, Maria Domencia Cappellini

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

Beta-thalassaemia is a congenital haemolytic anaemia characterized by partial (intermedia, TI) or complete (major, TM) deficiency in the production of β-globin chains. The primary aim of this study was to determine the prevalence of thromboembolic events in patients with β-thalassaemia. To achieve this, a multiple-choice questionnaire was sent to 56 tertiary referral centres in eight countries (Lebanon, Italy, Israel, Greece, Egypt, Jordan, Saudi Arabia and Iran), requesting specific information on patients who had experienced a thromboembolic event. The study demonstrated that thromboembolic events occurred in a clinically relevant proportion (1.65%) of 8,860 thalassaemia patients (TI - 24.7% orTM - 75.3%) from the Mediterranean and Iran. Thromboembolism occurred 4.38 times more frequently in TI thanTM (p

Original languageEnglish
Pages (from-to)488-491
Number of pages4
JournalThrombosis and Haemostasis
Volume96
Issue number4
DOIs
Publication statusPublished - Oct 2006

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beta-Thalassemia
Iran
Thalassemia
Congenital Hemolytic Anemia
Lebanon
Jordan
Globins
Saudi Arabia
Egypt
Greece
Thromboembolism
Israel
Tertiary Care Centers
Italy

Keywords

  • Thalassaemia intermedia
  • Thalassaemia major
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

Cite this

Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. / Taher, Ali; Isma'eel, Hussain; Mehio, Ghassan; Bignamini, Daniela; Kattamis, Antonis; Rachmilewitz, Eliezer A.; Cappellini, Maria Domencia.

In: Thrombosis and Haemostasis, Vol. 96, No. 4, 10.2006, p. 488-491.

Research output: Contribution to journalArticle

Taher, Ali ; Isma'eel, Hussain ; Mehio, Ghassan ; Bignamini, Daniela ; Kattamis, Antonis ; Rachmilewitz, Eliezer A. ; Cappellini, Maria Domencia. / Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. In: Thrombosis and Haemostasis. 2006 ; Vol. 96, No. 4. pp. 488-491.
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