Prevalence of thyroid autoimmunity in patients with spondyloarthropathies

Rosario Peluso, Gelsy Arianna Lupoli, Antonio Del Puente, Salvatore Iervolino, Vincenzo Bruner, Roberta Lupoli, Matteo Nicola Dario Di Minno, Francesca Foglia, Raffaele Scarpa, Giovanni Lupoli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. To evaluate the prevalence of chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) in a group of patients with spondyloarthritis (SpA). Methods. We evaluated serum levels of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine, and titers of antithyroglobulin and antithyroid peroxidase (anti-TPO) antibodies in 357 consecutive patients with SpA. We also recruited 318 healthy age-matched controls. Ultrasonography of the thyroid gland was performed in all subjects and rheumatic activity was evaluated. Results. Indices of thyroid autoimmunity were significantly more frequent in patients with SpA than in controls (24.09% vs 10.69%, respectively; p <0.05). In the SpA group, a higher prevalence of HT was found in patients with an active disease than in those with low-moderate disease levels. Also in the SpA group, patients with a disease duration > 2 years had a higher prevalence of HT and anti-TPO antibodies positivity than patients with a disease duration ≤ 2 years. Ultrasonography detected a significantly higher frequency of thyroid nodules and hypoechoic pattern in patients with SpA than in controls. Among patients with SpA, HT and anti-TPO antibodies positivity were significantly more frequent in patients with peripheral involvement (68.6%) than in patients with axial involvement (31.4%; p <0.05). Conclusion. Our study shows a significantly higher prevalence of thyroid autoimmunity in patients with SpA as compared to controls. Thyroiditis occurs more frequently in patients with longer disease duration and active rheumatic disease. We suggest that thyroid function tests be part of the clinical evaluation in patients with SpA. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalJournal of Rheumatology
Volume38
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Spondylarthropathies
Autoimmunity
Thyroid Gland
Hashimoto Disease
Peroxidase
Antibodies
Ultrasonography
Thyroid Function Tests
Autoimmune Thyroiditis
Thyroiditis
Thyroid Nodule
Rheumatology
Triiodothyronine
Thyrotropin
Rheumatic Diseases
Thyroxine

Keywords

  • Chronic autoimmune thyroiditis
  • Disease activity
  • Disease duration
  • Spondyloarthropathies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Peluso, R., Lupoli, G. A., Del Puente, A., Iervolino, S., Bruner, V., Lupoli, R., ... Lupoli, G. (2011). Prevalence of thyroid autoimmunity in patients with spondyloarthropathies. Journal of Rheumatology, 38(7), 1371-1377. https://doi.org/10.3899/jrheum.101012

Prevalence of thyroid autoimmunity in patients with spondyloarthropathies. / Peluso, Rosario; Lupoli, Gelsy Arianna; Del Puente, Antonio; Iervolino, Salvatore; Bruner, Vincenzo; Lupoli, Roberta; Di Minno, Matteo Nicola Dario; Foglia, Francesca; Scarpa, Raffaele; Lupoli, Giovanni.

In: Journal of Rheumatology, Vol. 38, No. 7, 07.2011, p. 1371-1377.

Research output: Contribution to journalArticle

Peluso, R, Lupoli, GA, Del Puente, A, Iervolino, S, Bruner, V, Lupoli, R, Di Minno, MND, Foglia, F, Scarpa, R & Lupoli, G 2011, 'Prevalence of thyroid autoimmunity in patients with spondyloarthropathies', Journal of Rheumatology, vol. 38, no. 7, pp. 1371-1377. https://doi.org/10.3899/jrheum.101012
Peluso R, Lupoli GA, Del Puente A, Iervolino S, Bruner V, Lupoli R et al. Prevalence of thyroid autoimmunity in patients with spondyloarthropathies. Journal of Rheumatology. 2011 Jul;38(7):1371-1377. https://doi.org/10.3899/jrheum.101012
Peluso, Rosario ; Lupoli, Gelsy Arianna ; Del Puente, Antonio ; Iervolino, Salvatore ; Bruner, Vincenzo ; Lupoli, Roberta ; Di Minno, Matteo Nicola Dario ; Foglia, Francesca ; Scarpa, Raffaele ; Lupoli, Giovanni. / Prevalence of thyroid autoimmunity in patients with spondyloarthropathies. In: Journal of Rheumatology. 2011 ; Vol. 38, No. 7. pp. 1371-1377.
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abstract = "Objective. To evaluate the prevalence of chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) in a group of patients with spondyloarthritis (SpA). Methods. We evaluated serum levels of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine, and titers of antithyroglobulin and antithyroid peroxidase (anti-TPO) antibodies in 357 consecutive patients with SpA. We also recruited 318 healthy age-matched controls. Ultrasonography of the thyroid gland was performed in all subjects and rheumatic activity was evaluated. Results. Indices of thyroid autoimmunity were significantly more frequent in patients with SpA than in controls (24.09{\%} vs 10.69{\%}, respectively; p <0.05). In the SpA group, a higher prevalence of HT was found in patients with an active disease than in those with low-moderate disease levels. Also in the SpA group, patients with a disease duration > 2 years had a higher prevalence of HT and anti-TPO antibodies positivity than patients with a disease duration ≤ 2 years. Ultrasonography detected a significantly higher frequency of thyroid nodules and hypoechoic pattern in patients with SpA than in controls. Among patients with SpA, HT and anti-TPO antibodies positivity were significantly more frequent in patients with peripheral involvement (68.6{\%}) than in patients with axial involvement (31.4{\%}; p <0.05). Conclusion. Our study shows a significantly higher prevalence of thyroid autoimmunity in patients with SpA as compared to controls. Thyroiditis occurs more frequently in patients with longer disease duration and active rheumatic disease. We suggest that thyroid function tests be part of the clinical evaluation in patients with SpA. The Journal of Rheumatology",
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