Prevalence of undiagnosed autoimmune rheumatic diseases in the first trimester of pregnancy. Results of a two-steps strategy using a self-administered questionnaire and autoantibody testing

A. Spinillo, F. Beneventi, O. M. Epis, L. Montanari, D. Mammoliti, V. Ramoni, E. Di Silverio, C. Alpini, R. Caporali, C. Montecucco

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2008

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First Pregnancy Trimester
Rheumatic Diseases
Autoantibodies
Autoimmune Diseases
Lupus Coagulation Inhibitor
Anticardiolipin Antibodies
Antibodies
Antinuclear Antibodies
Italy
Pregnant Women
Glycoproteins
Outcome Assessment (Health Care)
Surveys and Questionnaires
DNA
Population

Keywords

  • Autoimmune rheumatic disease
  • Fetal growth restriction
  • Screening

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Prevalence of undiagnosed autoimmune rheumatic diseases in the first trimester of pregnancy. Results of a two-steps strategy using a self-administered questionnaire and autoantibody testing",
abstract = "Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3{\%}) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1{\%} (59/137) among cases and 9.3{\%} (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5{\%}) and in none of the controls (P",
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author = "A. Spinillo and F. Beneventi and Epis, {O. M.} and L. Montanari and D. Mammoliti and V. Ramoni and {Di Silverio}, E. and C. Alpini and R. Caporali and C. Montecucco",
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AU - Spinillo, A.

AU - Beneventi, F.

AU - Epis, O. M.

AU - Montanari, L.

AU - Mammoliti, D.

AU - Ramoni, V.

AU - Di Silverio, E.

AU - Alpini, C.

AU - Caporali, R.

AU - Montecucco, C.

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N2 - Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P

AB - Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P

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KW - Fetal growth restriction

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