Prevalence of undiagnosed autoimmune rheumatic diseases in the first trimester of pregnancy. Results of a two-steps strategy using a self-administered questionnaire and autoantibody testing

A. Spinillo, F. Beneventi, O. M. Epis, L. Montanari, D. Mammoliti, V. Ramoni, E. Di Silverio, C. Alpini, R. Caporali, C. Montecucco

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Autoimmune rheumatic disease
  • Fetal growth restriction
  • Screening

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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