Abstract
Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P
| Original language | English |
|---|---|
| Pages (from-to) | 51-57 |
| Number of pages | 7 |
| Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
| Volume | 115 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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Keywords
- Autoimmune rheumatic disease
- Fetal growth restriction
- Screening
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Prevalence of undiagnosed autoimmune rheumatic diseases in the first trimester of pregnancy. Results of a two-steps strategy using a self-administered questionnaire and autoantibody testing. / Spinillo, A.; Beneventi, F.; Epis, O. M.; Montanari, L.; Mammoliti, D.; Ramoni, V.; Di Silverio, E.; Alpini, C.; Caporali, R.; Montecucco, C.
In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 115, No. 1, 01.2008, p. 51-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence of undiagnosed autoimmune rheumatic diseases in the first trimester of pregnancy. Results of a two-steps strategy using a self-administered questionnaire and autoantibody testing
AU - Spinillo, A.
AU - Beneventi, F.
AU - Epis, O. M.
AU - Montanari, L.
AU - Mammoliti, D.
AU - Ramoni, V.
AU - Di Silverio, E.
AU - Alpini, C.
AU - Caporali, R.
AU - Montecucco, C.
PY - 2008/1
Y1 - 2008/1
N2 - Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P
AB - Objective: To evaluate the prevalence of undiagnosed rheumatic diseases in the first trimester of pregnancy. Design: We screened for rheumatic diseases in 1210 consecutive pregnant women during the first trimester of pregnancy using a 10-item questionnaire. Setting: A university hospital in northern Italy. Population: One hundred and thirty-seven (11.3%) women who answered positively to at least one question constituted the cases and were compared with 107 negative controls. Methods: Cases and controls were tested for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibody, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and were evaluated by a rheumatologist for a definite diagnosis of rheumatic disease. Main outcome measures: Prevalence of undiagnosed rheumatic disease in the first trimester of pregnancy. Results: The overall rate of positivity to the antibodies tested was 43.1% (59/137) among cases and 9.3% (10/107) in the controls (P <0.001). A definitive diagnosis of rheumatic disease was made in 35 cases (25.5%) and in none of the controls (P
KW - Autoimmune rheumatic disease
KW - Fetal growth restriction
KW - Screening
UR - http://www.scopus.com/inward/record.url?scp=36749103741&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36749103741&partnerID=8YFLogxK
U2 - 10.1111/j.1471-0528.2007.01530.x
DO - 10.1111/j.1471-0528.2007.01530.x
M3 - Article
C2 - 17970796
AN - SCOPUS:36749103741
VL - 115
SP - 51
EP - 57
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 1
ER -