Abstract
The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is detectable in 39.3%. Microalbuminuria shows a significant negative correlation with left ventricular ejection fraction (Spearman's ρ = -0.228; p <0.001), while it is positively correlated with C-reactive protein (Spearman's ρ = 0.239; p <0.001), NT-pro-BNP (Spearman's ρ = 0.306; p <0.001) and glycemia (Spearman's ρ = 0.191; p <0.001). Microalbuminuria is an independent predictor for in-hospital mortality (1 μg/min step) (OR 1.015; 95% CI 1.008-1.023; p <0.001). In the acute phase of cardiac patients, microalbuminuria is a common finding, and it represents an independent predictor for early mortality. It is strictly linked to the inflammatory activation (as indicated by C-reactive protein) and to acute glucose values, thus suggesting that it may be part of the acute response to stress.
| Original language | English |
|---|---|
| Pages (from-to) | 327-331 |
| Number of pages | 5 |
| Journal | Internal and Emergency Medicine |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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Keywords
- Acute cardiac patients
- C-reactive protein
- Microalbuminuria
- Prognosis
ASJC Scopus subject areas
- Emergency Medicine
- Internal Medicine
Cite this
Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients : A single center experience. / Valente, Serafina; Lazzeri, Chiara; Chiostri, Marco; Alterini, Bruno; Ognibene, Agostino; Giglioli, Cristina; Pigozzi, Clara; Gensini, Gian Franco.
In: Internal and Emergency Medicine, Vol. 8, No. 4, 06.2013, p. 327-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevalence, predictors and prognostic significance of microalbuminuria in acute cardiac patients
T2 - A single center experience
AU - Valente, Serafina
AU - Lazzeri, Chiara
AU - Chiostri, Marco
AU - Alterini, Bruno
AU - Ognibene, Agostino
AU - Giglioli, Cristina
AU - Pigozzi, Clara
AU - Gensini, Gian Franco
PY - 2013/6
Y1 - 2013/6
N2 - The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is detectable in 39.3%. Microalbuminuria shows a significant negative correlation with left ventricular ejection fraction (Spearman's ρ = -0.228; p <0.001), while it is positively correlated with C-reactive protein (Spearman's ρ = 0.239; p <0.001), NT-pro-BNP (Spearman's ρ = 0.306; p <0.001) and glycemia (Spearman's ρ = 0.191; p <0.001). Microalbuminuria is an independent predictor for in-hospital mortality (1 μg/min step) (OR 1.015; 95% CI 1.008-1.023; p <0.001). In the acute phase of cardiac patients, microalbuminuria is a common finding, and it represents an independent predictor for early mortality. It is strictly linked to the inflammatory activation (as indicated by C-reactive protein) and to acute glucose values, thus suggesting that it may be part of the acute response to stress.
AB - The objective of this study was to prospectively assess the prevalence, predictors and prognostic significance of microalbuminuria in a large cohort of consecutive acute cardiac patients, admitted to an intensive cardiac care unit from 1 January 2008 to 30 June 2009. In 815 acute cardiac patients, microalbuminuria is detectable in 39.3%. Microalbuminuria shows a significant negative correlation with left ventricular ejection fraction (Spearman's ρ = -0.228; p <0.001), while it is positively correlated with C-reactive protein (Spearman's ρ = 0.239; p <0.001), NT-pro-BNP (Spearman's ρ = 0.306; p <0.001) and glycemia (Spearman's ρ = 0.191; p <0.001). Microalbuminuria is an independent predictor for in-hospital mortality (1 μg/min step) (OR 1.015; 95% CI 1.008-1.023; p <0.001). In the acute phase of cardiac patients, microalbuminuria is a common finding, and it represents an independent predictor for early mortality. It is strictly linked to the inflammatory activation (as indicated by C-reactive protein) and to acute glucose values, thus suggesting that it may be part of the acute response to stress.
KW - Acute cardiac patients
KW - C-reactive protein
KW - Microalbuminuria
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84878272116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878272116&partnerID=8YFLogxK
U2 - 10.1007/s11739-011-0619-2
DO - 10.1007/s11739-011-0619-2
M3 - Article
C2 - 21611780
AN - SCOPUS:84878272116
VL - 8
SP - 327
EP - 331
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 4
ER -