Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls

Laura Cremaschi, Mathias Kardell, Viktoria Johansson, Anniella Isgren, Carl M. Sellgren, A. Carlo Altamura, Christina M. Hultman, Mikael Landén

Research output: Contribution to journalArticle

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Abstract

Previous studies on the relationship between autoimmune diseases, schizophrenia, and bipolar disorder are mainly based on hospital discharge registers with insufficient coverage of outpatient data. Furthermore, data is scant on the prevalence of autoimmune diseases in bipolar subgroups. Here we estimate the self-reported prevalences of autoimmune diseases in schizophrenia, bipolar disorder type I and II, and controls. Lifetime prevalence of autoimmune diseases was assessed through a structured interview in a sample of 9076 patients (schizophrenia N = 5278, bipolar disorder type I N = 1952, type II N = 1846) and 6485 controls. Comparative analyses were performed using logistic regressions. The prevalence of diabetes type 1 did not differ between groups. Hyperthyroidism, hypothyroidism regardless of lithium effects, rheumatoid arthritis, and polymyalgia rheumatica were most common in bipolar disorder. Systemic lupus erythematosus was less common in bipolar disorder than in the other groups. The rate of autoimmune diseases did not differ significantly between bipolar subgroups. We conclude that prevalences of autoimmune diseases show clear differences between schizophrenia and bipolar disorder, but not between the bipolar subgroups.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalPsychiatry Research
Volume258
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Bipolar Disorder
Autoimmune Diseases
Schizophrenia
Polymyalgia Rheumatica
Hyperthyroidism
Hypothyroidism
Type 1 Diabetes Mellitus
Lithium
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Outpatients
Logistic Models
Interviews

Keywords

  • Bipolar disorder
  • Epidemiology
  • Neuroimmunology
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls. / Cremaschi, Laura; Kardell, Mathias; Johansson, Viktoria; Isgren, Anniella; Sellgren, Carl M.; Altamura, A. Carlo; Hultman, Christina M.; Landén, Mikael.

In: Psychiatry Research, Vol. 258, 01.12.2017, p. 9-14.

Research output: Contribution to journalArticle

Cremaschi, L, Kardell, M, Johansson, V, Isgren, A, Sellgren, CM, Altamura, AC, Hultman, CM & Landén, M 2017, 'Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls', Psychiatry Research, vol. 258, pp. 9-14. https://doi.org/10.1016/j.psychres.2017.09.071
Cremaschi, Laura ; Kardell, Mathias ; Johansson, Viktoria ; Isgren, Anniella ; Sellgren, Carl M. ; Altamura, A. Carlo ; Hultman, Christina M. ; Landén, Mikael. / Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls. In: Psychiatry Research. 2017 ; Vol. 258. pp. 9-14.
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