Preventing renal and cardiovascular risk by renal function assessment: Insights from a cross-sectional study in low-income countries and the USA

Paolo Cravedi, Sanjib Kumar Sharma, Rodolfo Flores Bravo, Nazmul Islam, Irma Tchokhonelidze, Madhav Ghimire, Bishnu Pahari, Sanjeev Thapa, Anil Basnet, Avtandil Tataradze, Davitaia Tinatin, Lela Beglarishvili, Chyng Wen Fwu, Jeffrey B. Kopp, Paul Eggers, Bogdan Ene-Iordache, Sergio Carminati, Annalisa Perna, Antonietta Chianca, William G. CouserGiuseppe Remuzzi, Norberto Perico

Research output: Contribution to journalArticle

Abstract

Objective: To assess the prevalence of microalbuminuria and kidney dysfunction in lowincome countries and in the USA. Design: Cross-sectional study of screening programmes in five countries. Setting: Screening programmes in Nepal, Bolivia, the USA (National Health and Nutrition Examination Survey (NHANES) 2005-2008) Bangladesh and Georgia. Participants: General population in Nepal (n=20 811), Bolivia (n=3436) and in the USA (n=4299) and highrisk subjects in Bangladesh (n=1518) and Georgia (n=1549). Primary and secondary outcome measures: Estimated glomerular filtration rate (eGFR)2 and microalbuminuria (defined as urinary albumin creatinine ratio values of 30-300 mg/g) were the main outcome measures. The cardiovascular (CV) risk was also evaluated on the basis of demographic, clinical and blood data. Results: The prevalence of eGFR2 were 8.6% and 4.9%, whereas those with microalbuminuria were 45.4% and 56.5%, respectively. Predicted 10-year CVD risk ≥10% was 25.4% and 25% in Bangladesh and Georgia, respectively. Conclusions: Renal abnormalities are common among low-income countries and in the USA. Prevention programmes, particularly focused on those with renal abnormalities, should be established worldwide to prevent CVD and progression to end-stage renal disease.

Original languageEnglish
Article numbere001357
JournalBMJ Open
Volume2
Issue number5
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Medicine(all)

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    Cravedi, P., Sharma, S. K., Bravo, R. F., Islam, N., Tchokhonelidze, I., Ghimire, M., Pahari, B., Thapa, S., Basnet, A., Tataradze, A., Tinatin, D., Beglarishvili, L., Fwu, C. W., Kopp, J. B., Eggers, P., Ene-Iordache, B., Carminati, S., Perna, A., Chianca, A., ... Perico, N. (2012). Preventing renal and cardiovascular risk by renal function assessment: Insights from a cross-sectional study in low-income countries and the USA. BMJ Open, 2(5), [e001357]. https://doi.org/10.1136/bmjopen-2012-001357