Preventing transmission of infectious agents in the pediatric in-patients hematology-oncology setting: What is the role for nonpharmacological prophylaxis?

Désirée Caselli, Simone Cesaro, Susanna Livadiotti, Ottavio Ziino, Olivia Paolicchi, Giulio Zanazzo, Giuseppe M. Milano, Maria Licciardello, Angelica Barone, Monica Cellini, De Santis Raffaella, Mareva Giacchino, Mario Renato Rossi, Maurizio Aricò, Elio Castagnola

Research output: Contribution to journalArticle

Abstract

The most intensive chemotherapy regimens were used in the past for leukemia patients who were the main focus of trials on infections; today there are increasing numbers of children with solid cancer and considerable risk of infection who do receive intensive stand ard-dose chemotherapy. Despite a continuous will to protect the immune-compromised child from infections, evidence-based indications for intervention by non-pharmacological tools is still lacking in the pediatric hematology-oncology literature. Guidelines on standard precautions as well as precautions to avoid transmission of specific infectious agents are available. As a result of a consensus discussion, the Italian Association for Pediatric Hematology-Oncology (AIEOP) Cooperative Group centers agree that for children treated with chemotherapy both of these approaches should be implemented and vigorously enforced, while additional policies, including strict environmental isolation, should be restricted to patients with selected clinical conditions or complications. We present here a study by the working group on infectious diseases of AIEOP.

Original languageEnglish
Article numbere9
JournalPediatric Reports
Volume3
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Chemotherapy
  • Infections
  • Leukemia
  • Pediatrics

ASJC Scopus subject areas

  • Pediatrics

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