Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14

F. Nicoletti, R. Di Marco, P. Sacerdote, P. Meroni, K. Mangano, C. Edwards, A. Bartorelli, K. Bendtzen, A. Panerai

Research output: Contribution to journalArticlepeer-review

Abstract

Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-α and IFN-γ in the blood.

Original languageEnglish
Pages (from-to)1591-1594
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number5
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14'. Together they form a unique fingerprint.

Cite this