Abstract
The conditions under which pretreatment with a calcium salt may prevent the action of reserpine on brain noradrenaline stores in the rat were investigated. The results show that only after subcutaneous administration of reserpine in the same site as a previous CaCl2 injection, was the action of reserpine prevented and reduced levels of this drug were found in the brain. Conversely, the depletion of encephalic noradrenaline following reserpine, as well as the reserpine brain concentration, were not affected by subcutaneously administered calcium chloride, when reserpine was administered either intravenously, or subcutaneously in a site different from that selected for pretreatment with the calcium salt. In essence calcium chloride, a well known irritant, acts accordingly at the site of subcutaneous administration, thus limiting by a non specific mechanism the absorption of reserpine. Under similar conditions, in fact, the absorption of a different drug, i.e. harmaline, was likewise altered. In view of these findings the significance of some studies on calcium reserpine interaction appearing in the literature requires a reappraisal.
| Original language | English |
|---|---|
| Pages (from-to) | 471-487 |
| Number of pages | 17 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 14 |
| Issue number | 3 |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Prevention by calcium administration of reserpine action on rat brain noradrenaline stores : a reappraisal. / Manara, L.; Cerletti, C.; Mennini, T.
In: Research Communications in Chemical Pathology and Pharmacology, Vol. 14, No. 3, 1976, p. 471-487.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention by calcium administration of reserpine action on rat brain noradrenaline stores
T2 - a reappraisal
AU - Manara, L.
AU - Cerletti, C.
AU - Mennini, T.
PY - 1976
Y1 - 1976
N2 - The conditions under which pretreatment with a calcium salt may prevent the action of reserpine on brain noradrenaline stores in the rat were investigated. The results show that only after subcutaneous administration of reserpine in the same site as a previous CaCl2 injection, was the action of reserpine prevented and reduced levels of this drug were found in the brain. Conversely, the depletion of encephalic noradrenaline following reserpine, as well as the reserpine brain concentration, were not affected by subcutaneously administered calcium chloride, when reserpine was administered either intravenously, or subcutaneously in a site different from that selected for pretreatment with the calcium salt. In essence calcium chloride, a well known irritant, acts accordingly at the site of subcutaneous administration, thus limiting by a non specific mechanism the absorption of reserpine. Under similar conditions, in fact, the absorption of a different drug, i.e. harmaline, was likewise altered. In view of these findings the significance of some studies on calcium reserpine interaction appearing in the literature requires a reappraisal.
AB - The conditions under which pretreatment with a calcium salt may prevent the action of reserpine on brain noradrenaline stores in the rat were investigated. The results show that only after subcutaneous administration of reserpine in the same site as a previous CaCl2 injection, was the action of reserpine prevented and reduced levels of this drug were found in the brain. Conversely, the depletion of encephalic noradrenaline following reserpine, as well as the reserpine brain concentration, were not affected by subcutaneously administered calcium chloride, when reserpine was administered either intravenously, or subcutaneously in a site different from that selected for pretreatment with the calcium salt. In essence calcium chloride, a well known irritant, acts accordingly at the site of subcutaneous administration, thus limiting by a non specific mechanism the absorption of reserpine. Under similar conditions, in fact, the absorption of a different drug, i.e. harmaline, was likewise altered. In view of these findings the significance of some studies on calcium reserpine interaction appearing in the literature requires a reappraisal.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017126718&partnerID=8YFLogxK
M3 - Article
C2 - 959653
AN - SCOPUS:0017126718
VL - 14
SP - 471
EP - 487
JO - Research Communications in Molecular Pathology and Pharmacology
JF - Research Communications in Molecular Pathology and Pharmacology
SN - 0034-5164
IS - 3
ER -