Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Rosanna Di Paola; Roberto Di Marco; Emanuela Mazzon; Tiziana Genovese; Klaus Bendtzen; Battesimo Macrì; Ferdinando Nicoletti; Salvatore Cuzzocrea

doi:10.1016/j.clim.2004.05.008

Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Rosanna Di Paola, Roberto Di Marco, Emanuela Mazzon, Tiziana Genovese, Klaus Bendtzen, Battesimo Macrì, Ferdinando Nicoletti, Salvatore Cuzzocrea

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

Original language	English
Pages (from-to)	64-73
Number of pages	10
Journal	Clinical Immunology
Volume	113
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2004.05.008
Publication status	Published - Oct 2004

Keywords

CD30L
Cytokine
Pleurisy

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.clim.2004.05.008

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Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody. / Di Paola, Rosanna; Di Marco, Roberto; Mazzon, Emanuela; Genovese, Tiziana; Bendtzen, Klaus; Macrì, Battesimo; Nicoletti, Ferdinando; Cuzzocrea, Salvatore.

In: Clinical Immunology, Vol. 113, No. 1, 10.2004, p. 64-73.

Research output: Contribution to journal › Article › peer-review

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abstract = "CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.",

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AU - Di Paola, Rosanna

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AU - Mazzon, Emanuela

AU - Genovese, Tiziana

AU - Bendtzen, Klaus

AU - Macrì, Battesimo

AU - Nicoletti, Ferdinando

AU - Cuzzocrea, Salvatore

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AB - CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.

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Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Abstract

Keywords

ASJC Scopus subject areas

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