Abstract
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
Original language | English |
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Pages (from-to) | 64-73 |
Number of pages | 10 |
Journal | Clinical Immunology |
Volume | 113 |
Issue number | 1 |
DOIs | |
Publication status | Published - Oct 2004 |
Keywords
- CD30L
- Cytokine
- Pleurisy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy