Abstract
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
| Original language | English |
|---|---|
| Pages (from-to) | 64-73 |
| Number of pages | 10 |
| Journal | Clinical Immunology |
| Volume | 113 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 2004 |
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Keywords
- CD30L
- Cytokine
- Pleurisy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody. / Di Paola, Rosanna; Di Marco, Roberto; Mazzon, Emanuela; Genovese, Tiziana; Bendtzen, Klaus; Macrì, Battesimo; Nicoletti, Ferdinando; Cuzzocrea, Salvatore.
In: Clinical Immunology, Vol. 113, No. 1, 10.2004, p. 64-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody
AU - Di Paola, Rosanna
AU - Di Marco, Roberto
AU - Mazzon, Emanuela
AU - Genovese, Tiziana
AU - Bendtzen, Klaus
AU - Macrì, Battesimo
AU - Nicoletti, Ferdinando
AU - Cuzzocrea, Salvatore
PY - 2004/10
Y1 - 2004/10
N2 - CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
AB - CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
KW - CD30L
KW - Cytokine
KW - Pleurisy
UR - http://www.scopus.com/inward/record.url?scp=6044241772&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=6044241772&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2004.05.008
DO - 10.1016/j.clim.2004.05.008
M3 - Article
C2 - 15380531
AN - SCOPUS:6044241772
VL - 113
SP - 64
EP - 73
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -