Prevention of compensatory ovarian hypertrophy by local treatment of the ovary with 6-OHDA

I. Gerendai, B. Marchetti, S. Maugeri

Research output: Contribution to journalArticlepeer-review

Abstract

The possible role of a neural mechanism involved in the development of compensatory ovarian hypertrophy has been studied. A new technique, the use of a special plastic capsule, has been developed to allow chronic local treatment of the ovary. Local treatment of one of the ovaries with 6-hydroxydopamine (6-OHDA) resulted in a weight increase in the other ovary. In the unilaterally ovariectomized rat the local application of 6-OHDA on the ovary blocked the development of compensatory ovarian hypertrophy. Local treatment of the ovary with dopamine (DA) did not interfere with the compensatory ovarian growth of the other ovary. Data suggest that intact adrenergic afferent and efferent neural elements of the ovary are required for the development of compensatory ovarian hypertrophy.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalNeuroendocrinology
Volume27
Issue number5-6
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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