Prevention of diabetes and cardiovascular disease in obesity

Lucia La Sala, Antonio E. Pontiroli

Research output: Contribution to journalReview articlepeer-review


Obesity is one of the major risk factors for the development of both impaired glucose tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide drives toward an increased rate of cardiovascular morbidity and mortality. Given the estimations of the World Health Organization (WHO) and the recommendation of the Diabetes Prevention Program (DPP), where IGT and diabetes are considered as risk factors for the development of cardiovascular complications and obesity, the development of diabetes should be treated because of its potential reversibility. In this view, several interventions such as diet, lifestyle changes, and pharmacological treatment are effective, including bariatric metabolic surgery (BMS), which is the most incisive way to efficiently lower body weight. In this review, we sought to summarize some of the major aspects linked to diabetes prevention in overweight/obesity, focusing on the use of surgery; we also attempted to elucidate molecular pathways involved in a variety of obesity-induced processes able to favor the progression of chronic diseases, such as diabetes and its complications.

Original languageEnglish
Article number8178
Pages (from-to)1-17
Number of pages17
JournalInternational Journal of Molecular Sciences
Issue number21
Publication statusPublished - Nov 1 2020


  • Atherosclerosis
  • Cardiovascular complications
  • CVD
  • Diabetes
  • Inflammation
  • Metabolic syndrome
  • MicroRNA
  • Obesity
  • Prevention
  • T2D

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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