Prevention of duodenal ulcer relapse with amoxycillin and omeprazole

Giancarlo C. Spinzi, Angelo Sangiovanni, Gianni Imperiali, Vittorio Terruzzi, Giorgio Minoli, Giorgio Baratelli, Mario Posca, Marcello Scarpis, Licia Snider

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To evaluate, prospectively, whether omeprazole and amoxycillin eradicate Helicobacter pylori and prevent duodenal ulcer relapse. Patients and Methods: This prospective multicentre trial included 53 patients. Twenty-nine H. pylori-positive patients were treated with omeprazole for 4 weeks (group A) and the remaining 24 received amoxycillin plus omeprazole for 2 weeks. Eradication of H. pylori was evaluated using the rapid urease test and histological examination. Results: Six months after the end of therapy, H. pylori was eradicated in two out of 23 patients (9%) from group A and 10 out of 21 (48%) from group B. The ulcer relapse rate was 68% (n = 15) for patients from group A and 17% (n = 3) for those from group B. Conclusion: Our regimen eradicated H. pylori in half of our patients and is effective in preventing ulcer relapse with few adverse events.

Original languageEnglish
Pages (from-to)599-602
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume6
Issue number7
Publication statusPublished - 1994

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Omeprazole
Amoxicillin
Duodenal Ulcer
Helicobacter pylori
Recurrence
Ulcer
Urease
Multicenter Studies

Keywords

  • Duodenal ulcer
  • Helicobacter pylori
  • Omeprazole

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Spinzi, G. C., Sangiovanni, A., Imperiali, G., Terruzzi, V., Minoli, G., Baratelli, G., ... Snider, L. (1994). Prevention of duodenal ulcer relapse with amoxycillin and omeprazole. European Journal of Gastroenterology and Hepatology, 6(7), 599-602.

Prevention of duodenal ulcer relapse with amoxycillin and omeprazole. / Spinzi, Giancarlo C.; Sangiovanni, Angelo; Imperiali, Gianni; Terruzzi, Vittorio; Minoli, Giorgio; Baratelli, Giorgio; Posca, Mario; Scarpis, Marcello; Snider, Licia.

In: European Journal of Gastroenterology and Hepatology, Vol. 6, No. 7, 1994, p. 599-602.

Research output: Contribution to journalArticle

Spinzi, GC, Sangiovanni, A, Imperiali, G, Terruzzi, V, Minoli, G, Baratelli, G, Posca, M, Scarpis, M & Snider, L 1994, 'Prevention of duodenal ulcer relapse with amoxycillin and omeprazole', European Journal of Gastroenterology and Hepatology, vol. 6, no. 7, pp. 599-602.
Spinzi, Giancarlo C. ; Sangiovanni, Angelo ; Imperiali, Gianni ; Terruzzi, Vittorio ; Minoli, Giorgio ; Baratelli, Giorgio ; Posca, Mario ; Scarpis, Marcello ; Snider, Licia. / Prevention of duodenal ulcer relapse with amoxycillin and omeprazole. In: European Journal of Gastroenterology and Hepatology. 1994 ; Vol. 6, No. 7. pp. 599-602.
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AU - Baratelli, Giorgio

AU - Posca, Mario

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AB - Objective: To evaluate, prospectively, whether omeprazole and amoxycillin eradicate Helicobacter pylori and prevent duodenal ulcer relapse. Patients and Methods: This prospective multicentre trial included 53 patients. Twenty-nine H. pylori-positive patients were treated with omeprazole for 4 weeks (group A) and the remaining 24 received amoxycillin plus omeprazole for 2 weeks. Eradication of H. pylori was evaluated using the rapid urease test and histological examination. Results: Six months after the end of therapy, H. pylori was eradicated in two out of 23 patients (9%) from group A and 10 out of 21 (48%) from group B. The ulcer relapse rate was 68% (n = 15) for patients from group A and 17% (n = 3) for those from group B. Conclusion: Our regimen eradicated H. pylori in half of our patients and is effective in preventing ulcer relapse with few adverse events.

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