Prevention of duodenal ulcer relapse with amoxycillin and omeprazole

Giancarlo C. Spinzi, Angelo Sangiovanni, Gianni Imperiali, Vittorio Terruzzi, Giorgio Minoli, Giorgio Baratelli, Mario Posca, Marcello Scarpis, Licia Snider

Research output: Contribution to journalArticle


Objective: To evaluate, prospectively, whether omeprazole and amoxycillin eradicate Helicobacter pylori and prevent duodenal ulcer relapse. Patients and Methods: This prospective multicentre trial included 53 patients. Twenty-nine H. pylori-positive patients were treated with omeprazole for 4 weeks (group A) and the remaining 24 received amoxycillin plus omeprazole for 2 weeks. Eradication of H. pylori was evaluated using the rapid urease test and histological examination. Results: Six months after the end of therapy, H. pylori was eradicated in two out of 23 patients (9%) from group A and 10 out of 21 (48%) from group B. The ulcer relapse rate was 68% (n = 15) for patients from group A and 17% (n = 3) for those from group B. Conclusion: Our regimen eradicated H. pylori in half of our patients and is effective in preventing ulcer relapse with few adverse events.

Original languageEnglish
Pages (from-to)599-602
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number7
Publication statusPublished - 1994


  • Duodenal ulcer
  • Helicobacter pylori
  • Omeprazole

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Spinzi, G. C., Sangiovanni, A., Imperiali, G., Terruzzi, V., Minoli, G., Baratelli, G., Posca, M., Scarpis, M., & Snider, L. (1994). Prevention of duodenal ulcer relapse with amoxycillin and omeprazole. European Journal of Gastroenterology and Hepatology, 6(7), 599-602.