Prevention of early postmenopausal bone loss. The effect of calcitonin (Staporos* * Staporos - Roussel Maestretti.)

Maria Pia Caraceni, Enzo Corghi, Sergio Ortolani, Moreno Dindelli, Guido Candottl, Augusto Ferrari

Research output: Contribution to journalArticle

Abstract

Bone and mineral metabolism was studied in 28 healthy women after surgical menopause. They were allocated randomly to an untreated group (Group 1) or a calcitonintreated group, porcine calcitonln (Staporos)* 3 iu per week for cycles of three months' treatment and one month interruption (Group 2) for two years. At one year of observation we recorded a significantly higher increase in urinary calcium and a significant decrease of forearm bone mineral density in the untreated group compared with the calcitonin-treated group. An increase in 1,25 dihydroxyvitamin D3 was seen in the calcitonin group. At two years of observation there were no important differences between the two groups, due probably to the non-compliance of two of the 10 women on calcitonin treatment. It is concluded that low doses of calcitonin are effective in preventing early postmenopausal bone loss.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalClinical Trials Journal
Volume25
Issue number6
Publication statusPublished - 1988

Keywords

  • calcitonin
  • oophorectomy
  • Postmenopausal osteoporosis

ASJC Scopus subject areas

  • Pharmacology (medical)

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