Bone and mineral metabolism was studied in 28 healthy women after surgical menopause. They were allocated randomly to an untreated group (Group 1) or a calcitonintreated group, porcine calcitonln (Staporos)* 3 iu per week for cycles of three months' treatment and one month interruption (Group 2) for two years. At one year of observation we recorded a significantly higher increase in urinary calcium and a significant decrease of forearm bone mineral density in the untreated group compared with the calcitonin-treated group. An increase in 1,25 dihydroxyvitamin D3 was seen in the calcitonin group. At two years of observation there were no important differences between the two groups, due probably to the non-compliance of two of the 10 women on calcitonin treatment. It is concluded that low doses of calcitonin are effective in preventing early postmenopausal bone loss.
|Number of pages||5|
|Journal||Clinical Trials Journal|
|Publication status||Published - 1988|
- Postmenopausal osteoporosis
ASJC Scopus subject areas
- Pharmacology (medical)