Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation: A prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach

Carlo Pappone, Francesco Manguso, Gabriele Vicedomini, Filippo Gugliotta, Ornella Santinelli, Amedeo Ferro, Simone Gulletta, Simone Sala, Nicoleta Sora, Gabriele Paglino, Giuseppe Augello, Eustachio Agricola, Alberto Zangrillo, Ottavio Alfieri, Vincenzo Santinelli

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

Background - Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the incidence of AT after PV ablation. Methods and Results - A total of 560 patients (291 men, 52%; age, 56.5±7.3 years) entered the study; 280 were randomized to CPVA alone (group 1) and 280 to modified CPVA (group 2). The primary end point was freedom from AT after the procedure. In group 1, 28 patients (10%) experienced new-onset AT, and 41 (14.3%) experienced recurrent AF. In group 2, 11 patients (3.9%) experienced AT, and 36 (12.9%) had recurrent AF. Group 1 was more likely to experience AT than group 2 (P=0.005). Freedom from AF after ablation was similar in both groups (P=0.57). Among those in group 1, gap-related macroreentrant AT was documented in 23 of the 28 patients (82%), and focal AT was found in 5 (18%). In group 2, gap-related macroreentrant AT was found in 8 of the 11 patients (73%), and focal AT was seen in 3 (27%). Two patients in group 1 and 1 patient in group 2 had both AT and AF. The strongest predictor of AT was the presence of gaps (P

Original languageEnglish
Pages (from-to)3036-3042
Number of pages7
JournalCirculation
Volume110
Issue number19
DOIs
Publication statusPublished - Nov 9 2004

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Pulmonary Veins
Tachycardia
Atrial Fibrillation
Prospective Studies

Keywords

  • Ablation
  • Fibrillation, atrial
  • Mapping
  • Tachycardia, ectopic atrial

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation : A prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach. / Pappone, Carlo; Manguso, Francesco; Vicedomini, Gabriele; Gugliotta, Filippo; Santinelli, Ornella; Ferro, Amedeo; Gulletta, Simone; Sala, Simone; Sora, Nicoleta; Paglino, Gabriele; Augello, Giuseppe; Agricola, Eustachio; Zangrillo, Alberto; Alfieri, Ottavio; Santinelli, Vincenzo.

In: Circulation, Vol. 110, No. 19, 09.11.2004, p. 3036-3042.

Research output: Contribution to journalArticle

Pappone, Carlo ; Manguso, Francesco ; Vicedomini, Gabriele ; Gugliotta, Filippo ; Santinelli, Ornella ; Ferro, Amedeo ; Gulletta, Simone ; Sala, Simone ; Sora, Nicoleta ; Paglino, Gabriele ; Augello, Giuseppe ; Agricola, Eustachio ; Zangrillo, Alberto ; Alfieri, Ottavio ; Santinelli, Vincenzo. / Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation : A prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach. In: Circulation. 2004 ; Vol. 110, No. 19. pp. 3036-3042.
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T1 - Prevention of iatrogenic atrial tachycardia after ablation of atrial fibrillation

T2 - A prospective randomized study comparing circumferential pulmonary vein ablation with a modified approach

AU - Pappone, Carlo

AU - Manguso, Francesco

AU - Vicedomini, Gabriele

AU - Gugliotta, Filippo

AU - Santinelli, Ornella

AU - Ferro, Amedeo

AU - Gulletta, Simone

AU - Sala, Simone

AU - Sora, Nicoleta

AU - Paglino, Gabriele

AU - Augello, Giuseppe

AU - Agricola, Eustachio

AU - Zangrillo, Alberto

AU - Alfieri, Ottavio

AU - Santinelli, Vincenzo

PY - 2004/11/9

Y1 - 2004/11/9

N2 - Background - Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the incidence of AT after PV ablation. Methods and Results - A total of 560 patients (291 men, 52%; age, 56.5±7.3 years) entered the study; 280 were randomized to CPVA alone (group 1) and 280 to modified CPVA (group 2). The primary end point was freedom from AT after the procedure. In group 1, 28 patients (10%) experienced new-onset AT, and 41 (14.3%) experienced recurrent AF. In group 2, 11 patients (3.9%) experienced AT, and 36 (12.9%) had recurrent AF. Group 1 was more likely to experience AT than group 2 (P=0.005). Freedom from AF after ablation was similar in both groups (P=0.57). Among those in group 1, gap-related macroreentrant AT was documented in 23 of the 28 patients (82%), and focal AT was found in 5 (18%). In group 2, gap-related macroreentrant AT was found in 8 of the 11 patients (73%), and focal AT was seen in 3 (27%). Two patients in group 1 and 1 patient in group 2 had both AT and AF. The strongest predictor of AT was the presence of gaps (P

AB - Background - Circumferential pulmonary vein ablation (CPVA) is effective in curing atrial fibrillation (AF), but new-onset left atrial tachycardia (AT) is a potential complication. We evaluated whether a modified CPVA approach including additional ablation lines on posterior wall and the mitral isthmus would reduce the incidence of AT after PV ablation. Methods and Results - A total of 560 patients (291 men, 52%; age, 56.5±7.3 years) entered the study; 280 were randomized to CPVA alone (group 1) and 280 to modified CPVA (group 2). The primary end point was freedom from AT after the procedure. In group 1, 28 patients (10%) experienced new-onset AT, and 41 (14.3%) experienced recurrent AF. In group 2, 11 patients (3.9%) experienced AT, and 36 (12.9%) had recurrent AF. Group 1 was more likely to experience AT than group 2 (P=0.005). Freedom from AF after ablation was similar in both groups (P=0.57). Among those in group 1, gap-related macroreentrant AT was documented in 23 of the 28 patients (82%), and focal AT was found in 5 (18%). In group 2, gap-related macroreentrant AT was found in 8 of the 11 patients (73%), and focal AT was seen in 3 (27%). Two patients in group 1 and 1 patient in group 2 had both AT and AF. The strongest predictor of AT was the presence of gaps (P

KW - Ablation

KW - Fibrillation, atrial

KW - Mapping

KW - Tachycardia, ectopic atrial

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