Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

M. Rocca; S. Capelli; M. Fini; M. C. Maltarello; F. M. Veronese; P. Caliceti; R. Giardino

Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

M. Rocca, S. Capelli, M. Fini, M. C. Maltarello, F. M. Veronese, P. Caliceti, R. Giardino

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

Original language	English
Pages (from-to)	125-132
Number of pages	8
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	71
Issue number	5-6
Publication status	Published - May 1995

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title = "Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.",

abstract = "The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.",

author = "M. Rocca and S. Capelli and M. Fini and Maltarello, {M. C.} and Veronese, {F. M.} and P. Caliceti and R. Giardino",

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AU - Rocca, M.

AU - Capelli, S.

AU - Fini, M.

AU - Maltarello, M. C.

AU - Veronese, F. M.

AU - Caliceti, P.

AU - Giardino, R.

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N2 - The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

AB - The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

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JF - Bollettino della Societa Italiana di Biologia Sperimentale

SN - 0037-8771

IS - 5-6

ER -

Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

Abstract

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