Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

M. Rocca, S. Capelli, M. Fini, M. C. Maltarello, F. M. Veronese, P. Caliceti, R. Giardino

Research output: Contribution to journalArticlepeer-review


The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number5-6
Publication statusPublished - May 1995


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