Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase.

M. Rocca, S. Capelli, M. Fini, M. C. Maltarello, F. M. Veronese, P. Caliceti, R. Giardino

Research output: Contribution to journalArticle

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Abstract

The efficacy of preventing ischemia-reperfusion damage by employing native or modified (mPEG-SOD) superoxide dismutase in an experimental model of acute ischemia was tested in the left hind limb of 43 Wistar rats. A significative difference (p=0.004) of the survival leg rate was found in the group treated with mPEG-SOD (86.6%) compared with the control group (30%). This difference was confirmed both clinically and by TEM analysis of muscular specimens.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume71
Issue number5-6
Publication statusPublished - May 1995

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Reperfusion Injury
Superoxide Dismutase
Ischemia
Wistar Rats
Leg
Theoretical Models
Extremities
Control Groups

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Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase. / Rocca, M.; Capelli, S.; Fini, M.; Maltarello, M. C.; Veronese, F. M.; Caliceti, P.; Giardino, R.

In: Bollettino della Societa Italiana di Biologia Sperimentale, Vol. 71, No. 5-6, 05.1995, p. 125-132.

Research output: Contribution to journalArticle

Rocca, M. ; Capelli, S. ; Fini, M. ; Maltarello, M. C. ; Veronese, F. M. ; Caliceti, P. ; Giardino, R. / Prevention of ischemia-reperfusion damage with polymerized superoxide dismutase. In: Bollettino della Societa Italiana di Biologia Sperimentale. 1995 ; Vol. 71, No. 5-6. pp. 125-132.
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