Prevention of lymphocele in female pelvic lymphadenectomy by a collagen patch coated with the human coagulation factors: A pilot study

Andrea Tinelli, Giorgio Giorda, Corrado Manca, Marcello Pellegrino, Raffaele Prudenzano, Marcello Guido, Domenico Dell'Edera, Antonio Malvasi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objectives The prevention of lymphoceles was tested using collagen patch coated with the human coagulation factors (TachoSil) on 58 consecutive patients with endometrial cancer who had undergone hysterectomy and pelvic lymphadenectomy (PL). Methods Patients were randomized in two groups: standard technique plus TachoSil (30 patients, group 1) and standard technique only (28, group 2). All surgical parameters were collected and patients underwent ultrasound examination on postoperative days 7, 14, and 28. The main outcome measures were: the development of symptomatic or asymptomatic lymphoceles, the need for further surgical intervention, as adverse effect of surgery and the drainage volume and duration. Results Same number of lymph nodes in both groups was removed; group 1 showed a lower drainage volume. Lymphoceles developed in 7 patients in group 1 and 16 in group 2, but only 3 were symptomatic in group 1 and 9 symptomatic in group 2, with statistical difference. Percutaneous drainage proved necessary in five cases: only one was in group 1 and four in group 2. Conclusions Intraoperative application of TachoSil reduced rate of postoperative lymphocysts after PL, and it seems to provide a useful additional treatment option for reducing drainage volume and preventing lymphocele development after PL.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalJournal of Surgical Oncology
Volume105
Issue number8
DOIs
Publication statusPublished - Jun 15 2012

Keywords

  • complications
  • drainage
  • endometrial cancer
  • lymph nodes
  • lymphocele
  • lymphocysts
  • pelvic lymphadenectomy
  • pelvis
  • radical hysterectomy

ASJC Scopus subject areas

  • Surgery
  • Oncology

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