Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice

L. Chieco Bianchi, D. Collavo, G. Biasi, A. Colombatti

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BALB/c mice born to and nursed by females immunized against Moloney murine sarcoma virus (MSV M) showed a reduced tumor incidence and a high tumor regression rate following MSV M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not. A reduced number of tumors was observed in 3 out of 14 MSV M injected litters whose mothers were previously exposed to the virus while nursing infected offspring. Sera from suckling mice born to and nursed by immunized mothers contained MSV M neutralizing antibody as shown by an in vitro focus reduction assay. Cell free extracts from mice which developed leukemia after MSV M inoculation were tested for oncogenic activity in 1 wk old mice. Out of 6 extracts, 4 induced typical MSV M tumors and 2 caused leukemias.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalBritish Journal of Cancer
Volume28
Issue number3
Publication statusPublished - 1973

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Murine Sarcoma Viruses
Carcinogenesis
Neoplasms
Leukemia
Moloney murine sarcoma virus
Neutralizing Antibodies
Cell Extracts
Nursing
Parturition
Viruses
Injections
Incidence
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chieco Bianchi, L., Collavo, D., Biasi, G., & Colombatti, A. (1973). Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. British Journal of Cancer, 28(3), 238-244.

Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. / Chieco Bianchi, L.; Collavo, D.; Biasi, G.; Colombatti, A.

In: British Journal of Cancer, Vol. 28, No. 3, 1973, p. 238-244.

Research output: Contribution to journalArticle

Chieco Bianchi, L, Collavo, D, Biasi, G & Colombatti, A 1973, 'Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice', British Journal of Cancer, vol. 28, no. 3, pp. 238-244.
Chieco Bianchi L, Collavo D, Biasi G, Colombatti A. Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. British Journal of Cancer. 1973;28(3):238-244.
Chieco Bianchi, L. ; Collavo, D. ; Biasi, G. ; Colombatti, A. / Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice. In: British Journal of Cancer. 1973 ; Vol. 28, No. 3. pp. 238-244.
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