Prevention of murine sarcoma virus oncogenesis in offspring of immunized female mice

L. Chieco Bianchi, D. Collavo, G. Biasi, A. Colombatti

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BALB/c mice born to and nursed by females immunized against Moloney murine sarcoma virus (MSV M) showed a reduced tumor incidence and a high tumor regression rate following MSV M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not. A reduced number of tumors was observed in 3 out of 14 MSV M injected litters whose mothers were previously exposed to the virus while nursing infected offspring. Sera from suckling mice born to and nursed by immunized mothers contained MSV M neutralizing antibody as shown by an in vitro focus reduction assay. Cell free extracts from mice which developed leukemia after MSV M inoculation were tested for oncogenic activity in 1 wk old mice. Out of 6 extracts, 4 induced typical MSV M tumors and 2 caused leukemias.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalBritish Journal of Cancer
Issue number3
Publication statusPublished - 1973

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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