BALB/c mice born to and nursed by females immunized against Moloney murine sarcoma virus (MSV M) showed a reduced tumor incidence and a high tumor regression rate following MSV M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not. A reduced number of tumors was observed in 3 out of 14 MSV M injected litters whose mothers were previously exposed to the virus while nursing infected offspring. Sera from suckling mice born to and nursed by immunized mothers contained MSV M neutralizing antibody as shown by an in vitro focus reduction assay. Cell free extracts from mice which developed leukemia after MSV M inoculation were tested for oncogenic activity in 1 wk old mice. Out of 6 extracts, 4 induced typical MSV M tumors and 2 caused leukemias.
|Number of pages||7|
|Journal||British Journal of Cancer|
|Publication status||Published - 1973|
ASJC Scopus subject areas
- Cancer Research