Prevention of Muscle and Nerve Damage after a Prolonged Ischemia/Reperfusion Syndrome: An Experimental Animal Model

M. Rocca, N. Nicoli Aldini, R. Giardino, P. Caliceti

Research output: Contribution to journalArticle

Abstract

An experimental rat model of limb replantation was developed to evaluate and compare the efficacy of SOD and mPEG-SOD (native and modified with polyethylene glycole superoxide dismutase) or PAcM-SOD (polyacriloilmorpholine superoxide dismutase) in preventing ischemia-reperfusion damage. In particular, the current research focused on the technical procedure employed for the study of the newly activated motor end-plates after ischemia/reperfusion injury. The experiment was carried out on 60 Wistar rats, randomly divided into four groups, submitted to 4 hours and 30 minutes of ischemia of the left hindlimb, followed by reperfusion. Results showed a beller limb survival in the mPEG-SOD group (87%) in comparison to other three groups (p

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of Applied Animal Research
Volume20
Issue number2
Publication statusPublished - Dec 2001

Keywords

  • Ischemia
  • Motor end plate
  • Muscle
  • Reperfusion

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Fingerprint Dive into the research topics of 'Prevention of Muscle and Nerve Damage after a Prolonged Ischemia/Reperfusion Syndrome: An Experimental Animal Model'. Together they form a unique fingerprint.

  • Cite this