Prevention of Muscle and Nerve Damage after a Prolonged Ischemia/Reperfusion Syndrome: An Experimental Animal Model

M. Rocca, N. Nicoli Aldini, R. Giardino, P. Caliceti

Research output: Contribution to journalArticle

Abstract

An experimental rat model of limb replantation was developed to evaluate and compare the efficacy of SOD and mPEG-SOD (native and modified with polyethylene glycole superoxide dismutase) or PAcM-SOD (polyacriloilmorpholine superoxide dismutase) in preventing ischemia-reperfusion damage. In particular, the current research focused on the technical procedure employed for the study of the newly activated motor end-plates after ischemia/reperfusion injury. The experiment was carried out on 60 Wistar rats, randomly divided into four groups, submitted to 4 hours and 30 minutes of ischemia of the left hindlimb, followed by reperfusion. Results showed a beller limb survival in the mPEG-SOD group (87%) in comparison to other three groups (p

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of Applied Animal Research
Volume20
Issue number2
Publication statusPublished - Dec 2001

Fingerprint

ischemia
Superoxide Dismutase
Reperfusion
laboratory animals
superoxide dismutase
nerve tissue
Ischemia
Animal Models
animal models
Polyethylene
Reperfusion Injury
Muscles
muscles
Extremities
limbs (animal)
polyethylene
Motor Endplate
Replantation
Hindlimb
Wistar Rats

Keywords

  • Ischemia
  • Motor end plate
  • Muscle
  • Reperfusion

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Prevention of Muscle and Nerve Damage after a Prolonged Ischemia/Reperfusion Syndrome : An Experimental Animal Model. / Rocca, M.; Nicoli Aldini, N.; Giardino, R.; Caliceti, P.

In: Journal of Applied Animal Research, Vol. 20, No. 2, 12.2001, p. 197-204.

Research output: Contribution to journalArticle

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