Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing: Long-term follow up

Luigi Padeletti, P. Pieragnoli, C. Ciapetti, A. Colefa, N. Musilli, M. C. Porciani, A. Michelucci, G. F. Gensini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Inter-atrial septum pacing may prevent initiation or persistence of atrial fibrillation through suppression of premature beats and regularization of atrial rhythm; prolongation of the coupling interval of the premature beats in the abnormal substrate; and modification of the electrophysiological properties of the substrate. The aim of the present study was to evaluate the rate of progression to permanent atrial fibrillation in patients paced at the inter-atrial septum. Method: A total of 70 patients (41 male, 29 female; mean age 72 ± 11 years) with a history of sinus bradycardia and paroxysmal atrial fibrillation (6 ± 10 episodes/month in the 3 months before implantation of a pacemaker) were enrolled. Twenty-six patients were ablated at the atrioventricular junction. Results: Sinus rhythm was maintained in 79.8% of the group overall after 50 months. After 36 months, sinus rhythm was maintained in 87.9% of the non-ablated patients and in 61.0% of the ablated patients (P <0.05). Conclusion: These results encourage further evaluation of interatrial septum pacing for prevention of AF.

Original languageEnglish
JournalEuropean Heart Journal, Supplement
Volume3
Issue numberP
DOIs
Publication statusPublished - 2001

Fingerprint

Atrial Fibrillation
Atrial Septum
Atrial Premature Complexes
Premature Cardiac Complexes
Bradycardia

Keywords

  • Atrial fibrillation
  • Atrioventricular node ablation
  • Septal atrial pacing
  • Sinus bradycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Padeletti, L., Pieragnoli, P., Ciapetti, C., Colefa, A., Musilli, N., Porciani, M. C., ... Gensini, G. F. (2001). Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing: Long-term follow up. European Heart Journal, Supplement, 3(P). https://doi.org/10.1016/S1520-765X(01)90066-5

Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing : Long-term follow up. / Padeletti, Luigi; Pieragnoli, P.; Ciapetti, C.; Colefa, A.; Musilli, N.; Porciani, M. C.; Michelucci, A.; Gensini, G. F.

In: European Heart Journal, Supplement, Vol. 3, No. P, 2001.

Research output: Contribution to journalArticle

Padeletti, L, Pieragnoli, P, Ciapetti, C, Colefa, A, Musilli, N, Porciani, MC, Michelucci, A & Gensini, GF 2001, 'Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing: Long-term follow up', European Heart Journal, Supplement, vol. 3, no. P. https://doi.org/10.1016/S1520-765X(01)90066-5
Padeletti, Luigi ; Pieragnoli, P. ; Ciapetti, C. ; Colefa, A. ; Musilli, N. ; Porciani, M. C. ; Michelucci, A. ; Gensini, G. F. / Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing : Long-term follow up. In: European Heart Journal, Supplement. 2001 ; Vol. 3, No. P.
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T2 - Long-term follow up

AU - Padeletti, Luigi

AU - Pieragnoli, P.

AU - Ciapetti, C.

AU - Colefa, A.

AU - Musilli, N.

AU - Porciani, M. C.

AU - Michelucci, A.

AU - Gensini, G. F.

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N2 - Background: Inter-atrial septum pacing may prevent initiation or persistence of atrial fibrillation through suppression of premature beats and regularization of atrial rhythm; prolongation of the coupling interval of the premature beats in the abnormal substrate; and modification of the electrophysiological properties of the substrate. The aim of the present study was to evaluate the rate of progression to permanent atrial fibrillation in patients paced at the inter-atrial septum. Method: A total of 70 patients (41 male, 29 female; mean age 72 ± 11 years) with a history of sinus bradycardia and paroxysmal atrial fibrillation (6 ± 10 episodes/month in the 3 months before implantation of a pacemaker) were enrolled. Twenty-six patients were ablated at the atrioventricular junction. Results: Sinus rhythm was maintained in 79.8% of the group overall after 50 months. After 36 months, sinus rhythm was maintained in 87.9% of the non-ablated patients and in 61.0% of the ablated patients (P <0.05). Conclusion: These results encourage further evaluation of interatrial septum pacing for prevention of AF.

AB - Background: Inter-atrial septum pacing may prevent initiation or persistence of atrial fibrillation through suppression of premature beats and regularization of atrial rhythm; prolongation of the coupling interval of the premature beats in the abnormal substrate; and modification of the electrophysiological properties of the substrate. The aim of the present study was to evaluate the rate of progression to permanent atrial fibrillation in patients paced at the inter-atrial septum. Method: A total of 70 patients (41 male, 29 female; mean age 72 ± 11 years) with a history of sinus bradycardia and paroxysmal atrial fibrillation (6 ± 10 episodes/month in the 3 months before implantation of a pacemaker) were enrolled. Twenty-six patients were ablated at the atrioventricular junction. Results: Sinus rhythm was maintained in 79.8% of the group overall after 50 months. After 36 months, sinus rhythm was maintained in 87.9% of the non-ablated patients and in 61.0% of the ablated patients (P <0.05). Conclusion: These results encourage further evaluation of interatrial septum pacing for prevention of AF.

KW - Atrial fibrillation

KW - Atrioventricular node ablation

KW - Septal atrial pacing

KW - Sinus bradycardia

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