Abstract
In a randomized multicenter clinical trial on antibiotic prophylaxis, 1,319 patients in 23 ICUs were enrolled over a 4-month period. The end-point of the study was the prevention of early onset pneumonia (EOP), defined as acquired pneumonia diagnosed within 4 days of ICU admission; this accounted for > 50% of overall pneumonia. Patients eligible for the study were divided into three groups which received either cefoxitin (2 g iv for three doses/8 h), penicillin G (2 million U iv for four doses/6 h), or no antibiotic (control group). In the overall population, the incidence of EOP was 6.1% in the prophylaxis recipients vs. 7.2% in the control group (a 15.3% reduction). No statistically different rates of pneumonia or death were found among the groups. Patients with impaired reflexes on admission or prolonged ventilatory support were noted to have a lower incidence of EOP and an improved outcome when treated with cefoxitin.
| Original language | English |
|---|---|
| Pages (from-to) | 501-505 |
| Number of pages | 5 |
| Journal | Critical Care Medicine |
| Volume | 17 |
| Issue number | 6 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Prevention of pneumonia in an intensive care unit : a randomized multicenter clinical trial. / Mandelli, M.; Mosconi, P.; Langer, M.; Cigada, M.; Arosio, G.; Bassi, F.; Beffagna, B.; Caroli, G. C.; Citterio, R.; Cusenza, A.; Emmi, V.; Ferrero, P.; Gallioli, G.; Lupi, P.; Malacrida, R.; Mascotto, G.; Minella, C.; Molinaroli, P.; Motta, F.
In: Critical Care Medicine, Vol. 17, No. 6, 1989, p. 501-505.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prevention of pneumonia in an intensive care unit
T2 - a randomized multicenter clinical trial
AU - Mandelli, M.
AU - Mosconi, P.
AU - Langer, M.
AU - Cigada, M.
AU - Arosio, G.
AU - Bassi, F.
AU - Beffagna, B.
AU - Caroli, G. C.
AU - Citterio, R.
AU - Cusenza, A.
AU - Emmi, V.
AU - Ferrero, P.
AU - Gallioli, G.
AU - Lupi, P.
AU - Malacrida, R.
AU - Mascotto, G.
AU - Minella, C.
AU - Molinaroli, P.
AU - Motta, F.
PY - 1989
Y1 - 1989
N2 - In a randomized multicenter clinical trial on antibiotic prophylaxis, 1,319 patients in 23 ICUs were enrolled over a 4-month period. The end-point of the study was the prevention of early onset pneumonia (EOP), defined as acquired pneumonia diagnosed within 4 days of ICU admission; this accounted for > 50% of overall pneumonia. Patients eligible for the study were divided into three groups which received either cefoxitin (2 g iv for three doses/8 h), penicillin G (2 million U iv for four doses/6 h), or no antibiotic (control group). In the overall population, the incidence of EOP was 6.1% in the prophylaxis recipients vs. 7.2% in the control group (a 15.3% reduction). No statistically different rates of pneumonia or death were found among the groups. Patients with impaired reflexes on admission or prolonged ventilatory support were noted to have a lower incidence of EOP and an improved outcome when treated with cefoxitin.
AB - In a randomized multicenter clinical trial on antibiotic prophylaxis, 1,319 patients in 23 ICUs were enrolled over a 4-month period. The end-point of the study was the prevention of early onset pneumonia (EOP), defined as acquired pneumonia diagnosed within 4 days of ICU admission; this accounted for > 50% of overall pneumonia. Patients eligible for the study were divided into three groups which received either cefoxitin (2 g iv for three doses/8 h), penicillin G (2 million U iv for four doses/6 h), or no antibiotic (control group). In the overall population, the incidence of EOP was 6.1% in the prophylaxis recipients vs. 7.2% in the control group (a 15.3% reduction). No statistically different rates of pneumonia or death were found among the groups. Patients with impaired reflexes on admission or prolonged ventilatory support were noted to have a lower incidence of EOP and an improved outcome when treated with cefoxitin.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024311707&partnerID=8YFLogxK
M3 - Article
VL - 17
SP - 501
EP - 505
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 6
ER -