Prevention of puerperal lactation by a single oral administration of the new prolactin-inhibiting drug, cabergoline

Gian Benedetto Melis, Valerio Mais, Anna Maria Paoletti, Fausta Beneventi, Marco Gambacciani, Piero Fioretti

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the efficacy of a single oral administration of the new ergot derivative Cabergoline in the prevention of postpartum lactation, we compared the effects of three different doses of the drug with those of placebo in 32 puerperal women. In a controlled, double-blind trial, the subjects were randomly allocated to four treatment groups receiving either placebo or 400, 600, or 800 μg Cabergoline (N = 8 in each group) within 24 hours after delivery. Treatment efficacy was assessed clinically by physical examination before (day 0) and at one, two, three, four, and 14 days after treatment. Plasma prolactin (PRL) concentrations were measured in blood samples collected before and at one, two, three, and four days after treatment. Lactation was prevented in four of the eight subjects (50%) who received 400 μg Cabergoline and in all subjects who received 600 or 800 μg Cabergoline. By contrast, only one of the eight subjects (12.5%) receiving placebo showed no signs of spontaneous lactation within the 14 days after delivery. No effects of placebo administration on plasma PRL levels were observed. Plasma PRL concentrations were significantly reduced starting from one day after Cabergoline administration, however, and the amount of inhibition of PRL secretion induced by different doses of the drug was not statistically different. These preliminary data demonstrate that Cabergoline has a dose-related effect in the prevention of postpartum lactation, and milk secretion can be prevented completely by a single oral administration of 600 or 800 μg of the drug.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalObstetrics and Gynecology
Volume71
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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