Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: A 12-month follow-up

A. Varricchio, G. Tortoriello, M. Capasso, A. De Lucia, P. Marchisio, A. M. Varricchio, N. Mansi, L. Giordano, G. Liberatore, M. Di Gioacchino, Giorgio Ciprandi

Research output: Contribution to journalArticle

Abstract

Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. One hundred seventy-eight children with a grade III or IV AH at baseline endoscopic examination were enrolled in this randomised and controlled study. Children were treated with intranasal flunisolide or isotonic saline solution for 8 weeks. Subsequent assessment, including history and fiberoptic endoscopy, was made at 8 weeks, and 6 and 12 months after treatment suspension. Flunisolide treatment was initially associated with significant (p

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalJournal of Biological Regulators and Homeostatic Agents
Volume23
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • 12-month follow-up
  • Adenoidal hypertrophy
  • Adenoidectomy
  • Children
  • Fiberoptic endoscopy
  • Intranasal corticosteroids
  • Intranasal flunisolide
  • Upper airway obstruction

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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  • Cite this

    Varricchio, A., Tortoriello, G., Capasso, M., De Lucia, A., Marchisio, P., Varricchio, A. M., Mansi, N., Giordano, L., Liberatore, G., Di Gioacchino, M., & Ciprandi, G. (2009). Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: A 12-month follow-up. Journal of Biological Regulators and Homeostatic Agents, 23(2), 95-101.