Abstract
Seizures represent the most common neurological emergency in ecstasy abusers; however, no study addressed whether (±) 3,4- methylenedioxymethamphetamine ("ecstasy") per se might produce long-lasting alterations in brain excitability related to a pro-convulsant effect. C57Black mice were treated with three regimens of (±) 3,4-methylenedioxymethamphetamine (5mg/kg×2 for 1, 2 or three consecutive days). Following the last dose of (±) 3,4-methylenedioxymethamphetamine, during a time interval of 8 weeks, the following procedures were carried out: 1) cortical electroencephalographic recordings, including power-spectrum analysis; 2) administration of sub-threshold doses of kainate; 3) measurement of regional [14C]2-deoxyglucose uptake; 4) monoamine assay. We demonstrate that all mice pre-treated with (±) 3,4-methylenedioxymethamphetamine showed long-lasting encephalographic changes with frequencies peaking at 3-4.5Hz at the power-spectrum analysis. This is concomitant with latent brain hyperexcitability within selected limbic brain regions, as shown by seizure facilitation and long-lasting latent metabolic hyperactivity which can be unraveled by phasic glutamate stimulation. This study sheds new light into the brain targets of (±) 3,4-methylenedioxymethamphetamine and discloses the occurrence of (±) 3,4-methylenedioxymethamphetamine-induced latent hyperexcitability within limbic areas, while it might provide a model to study in controlled experimental conditions limbic seizures and status epilepticus in C57Black mice. Persistent changes produced by (±) 3,4- methylenedioxymethamphetamine in limbic brain excitability might be responsible for seizures and limbic-related disorders in chronic (±) 3,4-methylenedioxymethamphetamine abusers.
| Original language | English |
|---|---|
| Pages (from-to) | 43-53 |
| Number of pages | 11 |
| Journal | Neuroscience |
| Volume | 136 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- [ C]2-DG
- Ecstasy
- EEG synchronization
- Epilepsy
- Kainate
- Limbic epilepsy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Previous exposure to (±) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility. / Giorgi, F. S.; Pizzanelli, C.; Ferrucci, M.; Lazzeri, G.; Faetti, M.; Giusiani, M.; Pontarelli, F.; Busceti, C. L.; Murri, L.; Fornai, F.
In: Neuroscience, Vol. 136, No. 1, 2005, p. 43-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Previous exposure to (±) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility
AU - Giorgi, F. S.
AU - Pizzanelli, C.
AU - Ferrucci, M.
AU - Lazzeri, G.
AU - Faetti, M.
AU - Giusiani, M.
AU - Pontarelli, F.
AU - Busceti, C. L.
AU - Murri, L.
AU - Fornai, F.
PY - 2005
Y1 - 2005
N2 - Seizures represent the most common neurological emergency in ecstasy abusers; however, no study addressed whether (±) 3,4- methylenedioxymethamphetamine ("ecstasy") per se might produce long-lasting alterations in brain excitability related to a pro-convulsant effect. C57Black mice were treated with three regimens of (±) 3,4-methylenedioxymethamphetamine (5mg/kg×2 for 1, 2 or three consecutive days). Following the last dose of (±) 3,4-methylenedioxymethamphetamine, during a time interval of 8 weeks, the following procedures were carried out: 1) cortical electroencephalographic recordings, including power-spectrum analysis; 2) administration of sub-threshold doses of kainate; 3) measurement of regional [14C]2-deoxyglucose uptake; 4) monoamine assay. We demonstrate that all mice pre-treated with (±) 3,4-methylenedioxymethamphetamine showed long-lasting encephalographic changes with frequencies peaking at 3-4.5Hz at the power-spectrum analysis. This is concomitant with latent brain hyperexcitability within selected limbic brain regions, as shown by seizure facilitation and long-lasting latent metabolic hyperactivity which can be unraveled by phasic glutamate stimulation. This study sheds new light into the brain targets of (±) 3,4-methylenedioxymethamphetamine and discloses the occurrence of (±) 3,4-methylenedioxymethamphetamine-induced latent hyperexcitability within limbic areas, while it might provide a model to study in controlled experimental conditions limbic seizures and status epilepticus in C57Black mice. Persistent changes produced by (±) 3,4- methylenedioxymethamphetamine in limbic brain excitability might be responsible for seizures and limbic-related disorders in chronic (±) 3,4-methylenedioxymethamphetamine abusers.
AB - Seizures represent the most common neurological emergency in ecstasy abusers; however, no study addressed whether (±) 3,4- methylenedioxymethamphetamine ("ecstasy") per se might produce long-lasting alterations in brain excitability related to a pro-convulsant effect. C57Black mice were treated with three regimens of (±) 3,4-methylenedioxymethamphetamine (5mg/kg×2 for 1, 2 or three consecutive days). Following the last dose of (±) 3,4-methylenedioxymethamphetamine, during a time interval of 8 weeks, the following procedures were carried out: 1) cortical electroencephalographic recordings, including power-spectrum analysis; 2) administration of sub-threshold doses of kainate; 3) measurement of regional [14C]2-deoxyglucose uptake; 4) monoamine assay. We demonstrate that all mice pre-treated with (±) 3,4-methylenedioxymethamphetamine showed long-lasting encephalographic changes with frequencies peaking at 3-4.5Hz at the power-spectrum analysis. This is concomitant with latent brain hyperexcitability within selected limbic brain regions, as shown by seizure facilitation and long-lasting latent metabolic hyperactivity which can be unraveled by phasic glutamate stimulation. This study sheds new light into the brain targets of (±) 3,4-methylenedioxymethamphetamine and discloses the occurrence of (±) 3,4-methylenedioxymethamphetamine-induced latent hyperexcitability within limbic areas, while it might provide a model to study in controlled experimental conditions limbic seizures and status epilepticus in C57Black mice. Persistent changes produced by (±) 3,4- methylenedioxymethamphetamine in limbic brain excitability might be responsible for seizures and limbic-related disorders in chronic (±) 3,4-methylenedioxymethamphetamine abusers.
KW - [ C]2-DG
KW - Ecstasy
KW - EEG synchronization
KW - Epilepsy
KW - Kainate
KW - Limbic epilepsy
UR - http://www.scopus.com/inward/record.url?scp=26944444296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26944444296&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2005.07.036
DO - 10.1016/j.neuroscience.2005.07.036
M3 - Article
VL - 136
SP - 43
EP - 53
JO - Neuroscience
JF - Neuroscience
SN - 0306-4522
IS - 1
ER -