Previous thyroid disease and risk of thyroid cancer in Switzerland

Fabio Levi, Silvia Franceschi, Carlo La Vecchia, Eva Negri, Cristina Gulie, Germaine Duruz, Bianca Scazziga

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

A hospital-based case-control study of 86 cases of thyroid cancer and 317 controls was done in the Swiss Canton of Vaud. Patients with thyroid cancer tended to be better educated (odds ratio [OR] 2.1 for ≥ 14 vs. ≤ 8 years of education 95% CI 1.1-4.1) and of higher social class than controls. Cases more often had a history of benign thyroid nodules (OR 25.2, 95% CI 7.6-83.6) and non-toxic goitre (OR 5.3, 95% CI 2.5-11.2). Furthermore, patients with thyroid cancer were more likely to have resided in endemic goitre areas (OR 1.7, 95% CI 1.0-3.0) and to have had first-degree relatives affected by benign thyroid disease (OR 3.9, 95% CI 2.1-7.1). Therefore, this study offers quantitative evidence of the association between various thyroid diseases and the risk of thyroid cancer which, despite difficulties in the classification of benign and malignant thyroid diseases, is remarkably consistent in studies from different countries.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Volume27
Issue number1
DOIs
Publication statusPublished - 1991

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Thyroid Diseases
Switzerland
Thyroid Neoplasms
Odds Ratio
Endemic Goiter
Thyroid Nodule
Goiter
Social Class
Case-Control Studies
Education

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Levi, F., Franceschi, S., La Vecchia, C., Negri, E., Gulie, C., Duruz, G., & Scazziga, B. (1991). Previous thyroid disease and risk of thyroid cancer in Switzerland. European Journal of Cancer and Clinical Oncology, 27(1), 85-88. https://doi.org/10.1016/0277-5379(91)90069-P

Previous thyroid disease and risk of thyroid cancer in Switzerland. / Levi, Fabio; Franceschi, Silvia; La Vecchia, Carlo; Negri, Eva; Gulie, Cristina; Duruz, Germaine; Scazziga, Bianca.

In: European Journal of Cancer and Clinical Oncology, Vol. 27, No. 1, 1991, p. 85-88.

Research output: Contribution to journalArticle

Levi, F, Franceschi, S, La Vecchia, C, Negri, E, Gulie, C, Duruz, G & Scazziga, B 1991, 'Previous thyroid disease and risk of thyroid cancer in Switzerland', European Journal of Cancer and Clinical Oncology, vol. 27, no. 1, pp. 85-88. https://doi.org/10.1016/0277-5379(91)90069-P
Levi, Fabio ; Franceschi, Silvia ; La Vecchia, Carlo ; Negri, Eva ; Gulie, Cristina ; Duruz, Germaine ; Scazziga, Bianca. / Previous thyroid disease and risk of thyroid cancer in Switzerland. In: European Journal of Cancer and Clinical Oncology. 1991 ; Vol. 27, No. 1. pp. 85-88.
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