Previous thyroid disease and risk of thyroid cancer in Switzerland

Fabio Levi, Silvia Franceschi, Carlo La Vecchia, Eva Negri, Cristina Gulie, Germaine Duruz, Bianca Scazziga

Research output: Contribution to journalArticle


A hospital-based case-control study of 86 cases of thyroid cancer and 317 controls was done in the Swiss Canton of Vaud. Patients with thyroid cancer tended to be better educated (odds ratio [OR] 2.1 for ≥ 14 vs. ≤ 8 years of education 95% CI 1.1-4.1) and of higher social class than controls. Cases more often had a history of benign thyroid nodules (OR 25.2, 95% CI 7.6-83.6) and non-toxic goitre (OR 5.3, 95% CI 2.5-11.2). Furthermore, patients with thyroid cancer were more likely to have resided in endemic goitre areas (OR 1.7, 95% CI 1.0-3.0) and to have had first-degree relatives affected by benign thyroid disease (OR 3.9, 95% CI 2.1-7.1). Therefore, this study offers quantitative evidence of the association between various thyroid diseases and the risk of thyroid cancer which, despite difficulties in the classification of benign and malignant thyroid diseases, is remarkably consistent in studies from different countries.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Levi, F., Franceschi, S., La Vecchia, C., Negri, E., Gulie, C., Duruz, G., & Scazziga, B. (1991). Previous thyroid disease and risk of thyroid cancer in Switzerland. European Journal of Cancer and Clinical Oncology, 27(1), 85-88.