Primary and recurrent retroperitoneal soft tissue sarcoma

Prognostic factors affecting survival

Antonio Chiappa, Andrew P. Zbar, Emilio Bertani, Roberto Biffi, Fabrizio Luca, Cristiano Crotti, Alessandro Testori, Gianluca Lazzaro, Tommaso De Pas, Pace Ugo, Bruno Andreoni

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background and Objectives: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). Conclusions: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalJournal of Surgical Oncology
Volume93
Issue number6
DOIs
Publication statusPublished - May 1 2006

Fingerprint

Sarcoma
Survival
Survival Analysis
Blood Transfusion
Disease-Free Survival
Neoplasms
Morbidity
Mortality

Keywords

  • Chemotherapy
  • Radiotherapy
  • Retroperitoneal sarcoma
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Primary and recurrent retroperitoneal soft tissue sarcoma : Prognostic factors affecting survival. / Chiappa, Antonio; Zbar, Andrew P.; Bertani, Emilio; Biffi, Roberto; Luca, Fabrizio; Crotti, Cristiano; Testori, Alessandro; Lazzaro, Gianluca; De Pas, Tommaso; Ugo, Pace; Andreoni, Bruno.

In: Journal of Surgical Oncology, Vol. 93, No. 6, 01.05.2006, p. 456-463.

Research output: Contribution to journalArticle

Chiappa, Antonio ; Zbar, Andrew P. ; Bertani, Emilio ; Biffi, Roberto ; Luca, Fabrizio ; Crotti, Cristiano ; Testori, Alessandro ; Lazzaro, Gianluca ; De Pas, Tommaso ; Ugo, Pace ; Andreoni, Bruno. / Primary and recurrent retroperitoneal soft tissue sarcoma : Prognostic factors affecting survival. In: Journal of Surgical Oncology. 2006 ; Vol. 93, No. 6. pp. 456-463.
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