Primary and recurrent retroperitoneal soft tissue sarcoma: Prognostic factors affecting survival

Antonio Chiappa, Andrew P. Zbar, Emilio Bertani, Roberto Biffi, Fabrizio Luca, Cristiano Crotti, Alessandro Testori, Gianluca Lazzaro, Tommaso De Pas, Pace Ugo, Bruno Andreoni

Research output: Contribution to journalArticle

Abstract

Background and Objectives: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). Conclusions: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalJournal of Surgical Oncology
Volume93
Issue number6
DOIs
Publication statusPublished - May 1 2006

Fingerprint

Sarcoma
Survival
Survival Analysis
Blood Transfusion
Disease-Free Survival
Neoplasms
Morbidity
Mortality

Keywords

  • Chemotherapy
  • Radiotherapy
  • Retroperitoneal sarcoma
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Primary and recurrent retroperitoneal soft tissue sarcoma : Prognostic factors affecting survival. / Chiappa, Antonio; Zbar, Andrew P.; Bertani, Emilio; Biffi, Roberto; Luca, Fabrizio; Crotti, Cristiano; Testori, Alessandro; Lazzaro, Gianluca; De Pas, Tommaso; Ugo, Pace; Andreoni, Bruno.

In: Journal of Surgical Oncology, Vol. 93, No. 6, 01.05.2006, p. 456-463.

Research output: Contribution to journalArticle

Chiappa, Antonio ; Zbar, Andrew P. ; Bertani, Emilio ; Biffi, Roberto ; Luca, Fabrizio ; Crotti, Cristiano ; Testori, Alessandro ; Lazzaro, Gianluca ; De Pas, Tommaso ; Ugo, Pace ; Andreoni, Bruno. / Primary and recurrent retroperitoneal soft tissue sarcoma : Prognostic factors affecting survival. In: Journal of Surgical Oncology. 2006 ; Vol. 93, No. 6. pp. 456-463.
@article{61b2c8674d4f48a2a4a7b4436dc94374,
title = "Primary and recurrent retroperitoneal soft tissue sarcoma: Prognostic factors affecting survival",
abstract = "Background and Objectives: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results: Twenty-eight out of 34 patients (82{\%}) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75{\%}) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21{\%}). High tumor grade results a significant variable for a worse survival in all 28 patients (100{\%} 5 years survival for low grade vs. 0{\%} for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). Conclusions: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.",
keywords = "Chemotherapy, Radiotherapy, Retroperitoneal sarcoma, Surgery, Survival",
author = "Antonio Chiappa and Zbar, {Andrew P.} and Emilio Bertani and Roberto Biffi and Fabrizio Luca and Cristiano Crotti and Alessandro Testori and Gianluca Lazzaro and {De Pas}, Tommaso and Pace Ugo and Bruno Andreoni",
year = "2006",
month = "5",
day = "1",
doi = "10.1002/jso.20446",
language = "English",
volume = "93",
pages = "456--463",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Primary and recurrent retroperitoneal soft tissue sarcoma

T2 - Prognostic factors affecting survival

AU - Chiappa, Antonio

AU - Zbar, Andrew P.

AU - Bertani, Emilio

AU - Biffi, Roberto

AU - Luca, Fabrizio

AU - Crotti, Cristiano

AU - Testori, Alessandro

AU - Lazzaro, Gianluca

AU - De Pas, Tommaso

AU - Ugo, Pace

AU - Andreoni, Bruno

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Background and Objectives: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). Conclusions: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.

AB - Background and Objectives: To analyze treatment and survival in 34 patients (28 resected) with primary or recurrent retroperitoneal sarcoma (RPS). Methods: Between July 1994 and January 2001, 34 patients (15M, 19F; mean age: 56 years, range: 25-77) were evaluated. Complete resection was defined as removal of gross tumor with histologically confirmed clear resection margins. Results: Twenty-eight out of 34 patients (82%) (15 were affected by primary RPS, and 13 by recurrent RPS), underwent surgical exploration. Twenty-three patients had a grossly and microscopically complete resection, (3 having a grossly incomplete resection and 2 patients with a grossly complete resection having histologically involved resection margins). Twenty-one out of 28 patients (75%) underwent removal of contiguous intra-abdominal organs. Preoperative mortality was nil, and morbidity occurred in six cases only (21%). High tumor grade results a significant variable for a worse survival in all 28 patients (100% 5 years survival for low grade vs. 0% for high grade; P = 0.0004). Amongst completely resected patients, only histologic grade and peroperative blood transfusions affected disease-free survival (P = 0.04 and P = 0.05, respectively). Conclusions: An aggressive surgical approach in both primary and recurrent RPS is associated with long-term survival.

KW - Chemotherapy

KW - Radiotherapy

KW - Retroperitoneal sarcoma

KW - Surgery

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=33646848420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646848420&partnerID=8YFLogxK

U2 - 10.1002/jso.20446

DO - 10.1002/jso.20446

M3 - Article

C2 - 16615149

AN - SCOPUS:33646848420

VL - 93

SP - 456

EP - 463

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 6

ER -