Abstract
This paper reviews the most relevant therapeutic results achieved by the Milan Cancer Institute through successive randomized studies in advanced Hodgkin's disease. The experience achieved confirms the therapeutic importance of an anthracycline-containing regimen such as ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) as salvage treatment and as primary chemotherapy, either when combined with irradiation or cyclically alternated with MOPP (mechlorethamine/vincristine/procarbazine/prednisone). Anthracycline-based combinations can be further refined to decrease toxicity. The biologic aspects of drug-sensitive v drug-resistant tumor cells and the accurate definition of prognostic categories at the time of first treatment failure are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 9-16 |
| Number of pages | 8 |
| Journal | Annals of Oncology |
| Volume | 2 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Cancer Research
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Primary and salvage chemotherapy in advanced Hodgkin's disease : The Milan Cancer Institute experience. / Bonadonna, G.; Santoro, A.; Gianni, A. M.; Viviani, S.; Siena, S.; Bregni, M.; Zucali, R.; Lombardi, F.; Bonfante, V.; Gianni, L.; Valagussa, P.
In: Annals of Oncology, Vol. 2, No. SUPPL. 1, 1991, p. 9-16.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary and salvage chemotherapy in advanced Hodgkin's disease
T2 - The Milan Cancer Institute experience
AU - Bonadonna, G.
AU - Santoro, A.
AU - Gianni, A. M.
AU - Viviani, S.
AU - Siena, S.
AU - Bregni, M.
AU - Zucali, R.
AU - Lombardi, F.
AU - Bonfante, V.
AU - Gianni, L.
AU - Valagussa, P.
PY - 1991
Y1 - 1991
N2 - This paper reviews the most relevant therapeutic results achieved by the Milan Cancer Institute through successive randomized studies in advanced Hodgkin's disease. The experience achieved confirms the therapeutic importance of an anthracycline-containing regimen such as ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) as salvage treatment and as primary chemotherapy, either when combined with irradiation or cyclically alternated with MOPP (mechlorethamine/vincristine/procarbazine/prednisone). Anthracycline-based combinations can be further refined to decrease toxicity. The biologic aspects of drug-sensitive v drug-resistant tumor cells and the accurate definition of prognostic categories at the time of first treatment failure are also discussed.
AB - This paper reviews the most relevant therapeutic results achieved by the Milan Cancer Institute through successive randomized studies in advanced Hodgkin's disease. The experience achieved confirms the therapeutic importance of an anthracycline-containing regimen such as ABVD (doxorubicin/bleomycin/vinblastine/dacarbazine) as salvage treatment and as primary chemotherapy, either when combined with irradiation or cyclically alternated with MOPP (mechlorethamine/vincristine/procarbazine/prednisone). Anthracycline-based combinations can be further refined to decrease toxicity. The biologic aspects of drug-sensitive v drug-resistant tumor cells and the accurate definition of prognostic categories at the time of first treatment failure are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=0026067722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026067722&partnerID=8YFLogxK
M3 - Article
C2 - 1710489
AN - SCOPUS:0026067722
VL - 2
SP - 9
EP - 16
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - SUPPL. 1
ER -