Primary and secondary hemostasis in patients with subclinical hypothyroidism: Effect of levothyroxine treatment

Roberta Lupoli, Matteo Nicola Dario Di Minno, Anna Tortora, Alessandra Scaravilli, Marianna Cacciapuoti, Livia Barba, Alessandro Di Minno, Pasquale Ambrosino, Gelsy Arianna Lupoli, Giovanni Lupoli

Research output: Contribution to journalArticle

Abstract

Context: Subclinical hypothyroidism (SH) is associated with some abnormalities in primary and secondary hemostasis. Objective: The objective of the study was to evaluate changes in primary and secondary hemostasis induced by levothyroxine (L-T4) treatment in SH patients. Design: This was a prospective cohort study with a 6-month follow-up. Study Setting: Outpatients were referred to "Federico II" University of Naples. Patients: Subjects with a SH without previous/ongoing L-T4 therapy participated in the study. Main Outcome Measure: Changes in major hemostatic/fibrinolytic variables and platelet reactivity [mean platelet volume (MPV), arachidonic acid (AA), or ADP concentrations inducing a ≥ 50% irreversible aggregation (AC-50%)] in SH patients before and after a 6-month L-T4 treatment. Results: At baseline, 41 SH patients showed higher levels of factor VII activity (123.9±20.4 vs 107.7±12.2, P

Original languageEnglish
Pages (from-to)2659-2665
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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    Lupoli, R., Di Minno, M. N. D., Tortora, A., Scaravilli, A., Cacciapuoti, M., Barba, L., Di Minno, A., Ambrosino, P., Lupoli, G. A., & Lupoli, G. (2015). Primary and secondary hemostasis in patients with subclinical hypothyroidism: Effect of levothyroxine treatment. Journal of Clinical Endocrinology and Metabolism, 100(7), 2659-2665. https://doi.org/10.1210/jc.2015-1726