Primary antiphospholipid syndrome and neurologic events

Viviana Rumi, Lucia Angelini, Vidmer Scaioli, Armando D'Angelo, Carlo Besana

Research output: Contribution to journalArticlepeer-review


The occurrence of lupus anticoagulant and anticardiolipin antibodies was demonstrated in a girl affected by recurrent episodes of visual disturbances, with ophthalmologic evidence of visual impairment and sometimes accompanied by migraine. Systemic lupus erythematosus was excluded on the basis of both clinical and serologic criteria and the diagnosis of primary antiphospholipid syndrome was made. Vascular pathogenesis was suggested by the characteristic symptoms. The serologic demonstration of antiphospholipid antibodies made it possible to relate the illness to an immune-mediated thrombotic tendency. This patient demonstrated that the diagnosis of primary antiphospholipid syndrome must always be considered in focal cerebral or retinal ischemia in childhood.

Original languageEnglish
Pages (from-to)473-475
Number of pages3
JournalPediatric Neurology
Issue number6
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology


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