TY - JOUR
T1 - Primary biliary cirrhosis is associated with specific changes in liver IgG-bearing cell subpopulations
AU - Torgano, Giuseppe
AU - Vecchi, Maurizio
AU - Podda, Mauro
AU - Zuin, Massimo
AU - Arosio, Eliana
AU - Battezzati, Pier Maria
AU - de Franchis, Robert
PY - 1995
Y1 - 1995
N2 - Background/Aims: The density of total IgG-bearing cells and the distribution of their subclasses were studied in the liver of patients with primary biliary cirrhosis. Methods: Immunohistochemistry and computerized image analysis were used to compare liver specimens from 18 patients with primary biliary cirrhosis and 28 with chronic hepatitis of different etiology. Results: The density of total IgG-bearing cells was similar in the two groups. However, in patients with primary biliary cirrhosis the proportion of IgG3-positive cells was significantly higher than in patients with chronic hepatitis (53±7% vs. 7.5±2.4%) (p-8). Conversely, IgG1-positive cells were significantly less prevalent in patients with primary biliary cirrhosis than in chronic hepatitis patients (27±6.9% vs. 68±7.2%, p-8). Stratification of patients with primary biliary cirrhosis according to histology did not show any difference in the distribution of IgG subclasses associated with the progression of disease. Conclusion: These data suggest a pathogenetic role of local IgG3-bearing cells in primary biliary cirrhosis.
AB - Background/Aims: The density of total IgG-bearing cells and the distribution of their subclasses were studied in the liver of patients with primary biliary cirrhosis. Methods: Immunohistochemistry and computerized image analysis were used to compare liver specimens from 18 patients with primary biliary cirrhosis and 28 with chronic hepatitis of different etiology. Results: The density of total IgG-bearing cells was similar in the two groups. However, in patients with primary biliary cirrhosis the proportion of IgG3-positive cells was significantly higher than in patients with chronic hepatitis (53±7% vs. 7.5±2.4%) (p-8). Conversely, IgG1-positive cells were significantly less prevalent in patients with primary biliary cirrhosis than in chronic hepatitis patients (27±6.9% vs. 68±7.2%, p-8). Stratification of patients with primary biliary cirrhosis according to histology did not show any difference in the distribution of IgG subclasses associated with the progression of disease. Conclusion: These data suggest a pathogenetic role of local IgG3-bearing cells in primary biliary cirrhosis.
KW - Autoantibodies to mitochondria
KW - B-lymphocytes
KW - Immunohistochemistry.
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U2 - 10.1016/0168-8278(95)80449-8
DO - 10.1016/0168-8278(95)80449-8
M3 - Article
C2 - 7650335
AN - SCOPUS:0029004301
VL - 22
SP - 545
EP - 550
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 5
ER -