From 1981 to 1988 approximately 320 patients with non-Hodgkin's lymphoma were treated at the Division of Medical Oncology, Medical School II, University of Naples, Naples, Italy. In 11, bone was the primary site of involvement; nine of 11 had high grade lymphoma. After accurate clinical-pathologic staging only three patients had true solitary bone lymphoma (in two cases localized at the rachis and in the third at the humerus), while the rest showed Working Formulation stage IV disease. All patients, including those with solitary disease, received chemotherapy for a total of six to eight courses. The three patients with solitary lymphoma also received local radiotherapy (4,000 rads). Eight of 11 achieved a complete response and at a 45-month median follow-up six patients were still alive and disease-free. The three patients with true solitary bone lymphoma are disease free after 4, 4, and 5 years from diagnosis. Lymphoma primarily involving bone does not appear to have a worse prognosis than the other lymphomas. True solitary bone lymphoma is rarer today than in the past because of more accurate staging procedures. It may have a good prognosis providing that combined radio-chemotherapy is performed in the high-grade histologic subgroups.
|Number of pages||5|
|Journal||Current Therapeutic Research|
|Publication status||Published - 1990|
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