Primary bone lymphoma: Experience with 52 patients

Piér Luigi Zinzani, Giovanna Carrillo, Stefano Ascani, Enza Barbieri, Monica Tani, Marco Paulli, Vittorio Stefoni, Elena Sabattini, Lapo Alinari, Roberto Binazzi, Sante Tura, Michele Baccarani, Stefano A. Pileri

Research output: Contribution to journalArticle

Abstract

Background and Objectives. A retrospective analysis was performed to assess the efficacy of various treatments of non-Hodgkin's primary bone lymphomas (PBL). Design and Methods. Fifty-two consecutive, previously untreated PBL patients were seen between the years 1982 and 1998. Information was obtained regarding each patient's presentation and clinical course. Histology was reviewed in all cases. Modern immunohistochemical stains were performed on each case. Results. Regarding therapeutic approach, we observed a complete response (CR) in 35/41 (85%) patients treated with chemotherapy with/without radiation therapy and in 7/11 (64%) patients who received radiation therapy alone. Relapses were observed in only 2/35 (6%) patients after chemotherapy (with/without radiation therapy), as compared with 4/7 (57%) patients after radiation therapy alone (p = 0.004); the relapse-free survival curves of these two subsets were significantly different. At both univariate and multivariate analysis only type of front-line therapeutic approach (chemotherapy with/without radiation therapy vs. radiation therapy alone) turned out to have a significant prognostic influence. Interpretation and Conclusions. Our data indicate that in PBL use of chemotherapy or combined-modality therapy seems to provide more durable CRs than radiation therapy alone.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalHaematologica
Volume88
Issue number3
Publication statusPublished - Mar 1 2003

Fingerprint

Lymphoma
Radiotherapy
Bone and Bones
Drug Therapy
Recurrence
Combined Modality Therapy
Non-Hodgkin's Lymphoma
Histology
Coloring Agents
Multivariate Analysis
Survival
Therapeutics

Keywords

  • Chemotherapy
  • Primary bone lymphoma
  • Radiation therapy

ASJC Scopus subject areas

  • Hematology

Cite this

Zinzani, P. L., Carrillo, G., Ascani, S., Barbieri, E., Tani, M., Paulli, M., ... Pileri, S. A. (2003). Primary bone lymphoma: Experience with 52 patients. Haematologica, 88(3), 280-285.

Primary bone lymphoma : Experience with 52 patients. / Zinzani, Piér Luigi; Carrillo, Giovanna; Ascani, Stefano; Barbieri, Enza; Tani, Monica; Paulli, Marco; Stefoni, Vittorio; Sabattini, Elena; Alinari, Lapo; Binazzi, Roberto; Tura, Sante; Baccarani, Michele; Pileri, Stefano A.

In: Haematologica, Vol. 88, No. 3, 01.03.2003, p. 280-285.

Research output: Contribution to journalArticle

Zinzani, PL, Carrillo, G, Ascani, S, Barbieri, E, Tani, M, Paulli, M, Stefoni, V, Sabattini, E, Alinari, L, Binazzi, R, Tura, S, Baccarani, M & Pileri, SA 2003, 'Primary bone lymphoma: Experience with 52 patients', Haematologica, vol. 88, no. 3, pp. 280-285.
Zinzani PL, Carrillo G, Ascani S, Barbieri E, Tani M, Paulli M et al. Primary bone lymphoma: Experience with 52 patients. Haematologica. 2003 Mar 1;88(3):280-285.
Zinzani, Piér Luigi ; Carrillo, Giovanna ; Ascani, Stefano ; Barbieri, Enza ; Tani, Monica ; Paulli, Marco ; Stefoni, Vittorio ; Sabattini, Elena ; Alinari, Lapo ; Binazzi, Roberto ; Tura, Sante ; Baccarani, Michele ; Pileri, Stefano A. / Primary bone lymphoma : Experience with 52 patients. In: Haematologica. 2003 ; Vol. 88, No. 3. pp. 280-285.
@article{9c77cc78e61a45579a9dc698eb20b865,
title = "Primary bone lymphoma: Experience with 52 patients",
abstract = "Background and Objectives. A retrospective analysis was performed to assess the efficacy of various treatments of non-Hodgkin's primary bone lymphomas (PBL). Design and Methods. Fifty-two consecutive, previously untreated PBL patients were seen between the years 1982 and 1998. Information was obtained regarding each patient's presentation and clinical course. Histology was reviewed in all cases. Modern immunohistochemical stains were performed on each case. Results. Regarding therapeutic approach, we observed a complete response (CR) in 35/41 (85{\%}) patients treated with chemotherapy with/without radiation therapy and in 7/11 (64{\%}) patients who received radiation therapy alone. Relapses were observed in only 2/35 (6{\%}) patients after chemotherapy (with/without radiation therapy), as compared with 4/7 (57{\%}) patients after radiation therapy alone (p = 0.004); the relapse-free survival curves of these two subsets were significantly different. At both univariate and multivariate analysis only type of front-line therapeutic approach (chemotherapy with/without radiation therapy vs. radiation therapy alone) turned out to have a significant prognostic influence. Interpretation and Conclusions. Our data indicate that in PBL use of chemotherapy or combined-modality therapy seems to provide more durable CRs than radiation therapy alone.",
keywords = "Chemotherapy, Primary bone lymphoma, Radiation therapy",
author = "Zinzani, {Pi{\'e}r Luigi} and Giovanna Carrillo and Stefano Ascani and Enza Barbieri and Monica Tani and Marco Paulli and Vittorio Stefoni and Elena Sabattini and Lapo Alinari and Roberto Binazzi and Sante Tura and Michele Baccarani and Pileri, {Stefano A.}",
year = "2003",
month = "3",
day = "1",
language = "English",
volume = "88",
pages = "280--285",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "3",

}

TY - JOUR

T1 - Primary bone lymphoma

T2 - Experience with 52 patients

AU - Zinzani, Piér Luigi

AU - Carrillo, Giovanna

AU - Ascani, Stefano

AU - Barbieri, Enza

AU - Tani, Monica

AU - Paulli, Marco

AU - Stefoni, Vittorio

AU - Sabattini, Elena

AU - Alinari, Lapo

AU - Binazzi, Roberto

AU - Tura, Sante

AU - Baccarani, Michele

AU - Pileri, Stefano A.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Background and Objectives. A retrospective analysis was performed to assess the efficacy of various treatments of non-Hodgkin's primary bone lymphomas (PBL). Design and Methods. Fifty-two consecutive, previously untreated PBL patients were seen between the years 1982 and 1998. Information was obtained regarding each patient's presentation and clinical course. Histology was reviewed in all cases. Modern immunohistochemical stains were performed on each case. Results. Regarding therapeutic approach, we observed a complete response (CR) in 35/41 (85%) patients treated with chemotherapy with/without radiation therapy and in 7/11 (64%) patients who received radiation therapy alone. Relapses were observed in only 2/35 (6%) patients after chemotherapy (with/without radiation therapy), as compared with 4/7 (57%) patients after radiation therapy alone (p = 0.004); the relapse-free survival curves of these two subsets were significantly different. At both univariate and multivariate analysis only type of front-line therapeutic approach (chemotherapy with/without radiation therapy vs. radiation therapy alone) turned out to have a significant prognostic influence. Interpretation and Conclusions. Our data indicate that in PBL use of chemotherapy or combined-modality therapy seems to provide more durable CRs than radiation therapy alone.

AB - Background and Objectives. A retrospective analysis was performed to assess the efficacy of various treatments of non-Hodgkin's primary bone lymphomas (PBL). Design and Methods. Fifty-two consecutive, previously untreated PBL patients were seen between the years 1982 and 1998. Information was obtained regarding each patient's presentation and clinical course. Histology was reviewed in all cases. Modern immunohistochemical stains were performed on each case. Results. Regarding therapeutic approach, we observed a complete response (CR) in 35/41 (85%) patients treated with chemotherapy with/without radiation therapy and in 7/11 (64%) patients who received radiation therapy alone. Relapses were observed in only 2/35 (6%) patients after chemotherapy (with/without radiation therapy), as compared with 4/7 (57%) patients after radiation therapy alone (p = 0.004); the relapse-free survival curves of these two subsets were significantly different. At both univariate and multivariate analysis only type of front-line therapeutic approach (chemotherapy with/without radiation therapy vs. radiation therapy alone) turned out to have a significant prognostic influence. Interpretation and Conclusions. Our data indicate that in PBL use of chemotherapy or combined-modality therapy seems to provide more durable CRs than radiation therapy alone.

KW - Chemotherapy

KW - Primary bone lymphoma

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=0347296212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347296212&partnerID=8YFLogxK

M3 - Article

C2 - 12651266

AN - SCOPUS:0347296212

VL - 88

SP - 280

EP - 285

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 3

ER -