Primary cutaneous plasmablastic lymphoma as first sign of human immunodeficiency virus infection

Carlo Cota, Viviana Lora, Lorenzo Cerroni

Research output: Contribution to journalArticlepeer-review

Abstract

Plasmablastic lymphoma (PBL) is an uncommon lymphoid neoplasm characterized by a diffuse proliferation of large neoplastic cells similar to B immunoblasts but with immunophenotypic features resembling plasma cells, originally reported in the oral cavity in human immunodeficiency virus-infected patients. This lymphoma may be observed also in the setting of other types of immune suppression and even in non-immune-suppressed individuals. We report on a 48-year-old man who presented with a large, exophytic tumor of 3-month duration located to the sacral region, classified as PBL upon histopathologic and phenotypic features. The lymphoma represented the first sign of a yet undiagnosed infection by human immunodeficiency virus. This review addresses the clinical, histopathologic, phenotypic, differential diagnostic, and prognostic features of cutaneous PBL.

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalPathology Case Reviews
Volume19
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Epstein-Barr virus
  • human immunodeficiency virus
  • plasmablastic lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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