TY - JOUR
T1 - Primary cutaneous plasmablastic lymphoma as first sign of human immunodeficiency virus infection
AU - Cota, Carlo
AU - Lora, Viviana
AU - Cerroni, Lorenzo
PY - 2014
Y1 - 2014
N2 - Plasmablastic lymphoma (PBL) is an uncommon lymphoid neoplasm characterized by a diffuse proliferation of large neoplastic cells similar to B immunoblasts but with immunophenotypic features resembling plasma cells, originally reported in the oral cavity in human immunodeficiency virus-infected patients. This lymphoma may be observed also in the setting of other types of immune suppression and even in non-immune-suppressed individuals. We report on a 48-year-old man who presented with a large, exophytic tumor of 3-month duration located to the sacral region, classified as PBL upon histopathologic and phenotypic features. The lymphoma represented the first sign of a yet undiagnosed infection by human immunodeficiency virus. This review addresses the clinical, histopathologic, phenotypic, differential diagnostic, and prognostic features of cutaneous PBL.
AB - Plasmablastic lymphoma (PBL) is an uncommon lymphoid neoplasm characterized by a diffuse proliferation of large neoplastic cells similar to B immunoblasts but with immunophenotypic features resembling plasma cells, originally reported in the oral cavity in human immunodeficiency virus-infected patients. This lymphoma may be observed also in the setting of other types of immune suppression and even in non-immune-suppressed individuals. We report on a 48-year-old man who presented with a large, exophytic tumor of 3-month duration located to the sacral region, classified as PBL upon histopathologic and phenotypic features. The lymphoma represented the first sign of a yet undiagnosed infection by human immunodeficiency virus. This review addresses the clinical, histopathologic, phenotypic, differential diagnostic, and prognostic features of cutaneous PBL.
KW - Epstein-Barr virus
KW - human immunodeficiency virus
KW - plasmablastic lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84907369009&partnerID=8YFLogxK
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U2 - 10.1097/PCR.0000000000000040
DO - 10.1097/PCR.0000000000000040
M3 - Article
AN - SCOPUS:84907369009
VL - 19
SP - 204
EP - 207
JO - Pathology Case Reviews
JF - Pathology Case Reviews
SN - 1082-9784
IS - 4
ER -