Primary cutaneous pleomorphic T-cell lymphoma expressing CD30 antigen

R. Gianotti, E. Alessi, S. Cavicchini, E. Berti

Research output: Contribution to journalArticlepeer-review

Abstract

Pleomorphic peripheral T-cell lymphomas (PPTL) arising primarily in the skin are uncommon. The observation of pleomorphic T-cell lymphoma composed of 100% CD30+ cells is rare. We report the case of a woman in whom such a tumor manifested itself with a single cutaneous lesion. It was composed of medium to large cells expressing markers of helper/inducer T-lymphocytes, as well as activation (CD30) and proliferation antigens (Ki-67), but not the CD25 activation antigen. The lesion was excised and the patient is alive and disease free 2 years after the diagnosis. This case confirms previous reports about the favorable course of some cutaneous pleomorphic lymphomas, and shows that the activation antigen expression and proliferation antigen (Ki-67) expression do not seem to worsen the prognosis.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalAmerican Journal of Dermatopathology
Volume13
Issue number5
Publication statusPublished - 1991

Keywords

  • Lymphoproliferative disorders
  • Pleomorphic peripheral T-cell lymphoma
  • Primary cutaneous CD30 lymphomas

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

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