Primary diffuse large B-cell lymphoma of the uterus: Case report and review

Vincenzo Dario Mandato, Rosalba Palermo, Angela Falbo, Isabella Capodanno, Francesco Capodanno, Maria Carolina Gelli, Lorenzo Aguzzoli, Martino Abrate, Giovanni Battista La Sala

Research output: Contribution to journalArticle

Abstract

Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.

Original languageEnglish
Pages (from-to)4377-4390
Number of pages14
JournalAnticancer Research
Volume34
Issue number8
Publication statusPublished - Aug 1 2014

Keywords

  • Cervix
  • Diagnosis
  • Lymphoma
  • Treatment
  • Uterus
  • Vaginal bleeding

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Mandato, V. D., Palermo, R., Falbo, A., Capodanno, I., Capodanno, F., Gelli, M. C., Aguzzoli, L., Abrate, M., & La Sala, G. B. (2014). Primary diffuse large B-cell lymphoma of the uterus: Case report and review. Anticancer Research, 34(8), 4377-4390.