Abstract
Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.
| Original language | English |
|---|---|
| Pages (from-to) | 4377-4390 |
| Number of pages | 14 |
| Journal | Anticancer Research |
| Volume | 34 |
| Issue number | 8 |
| Publication status | Published - Aug 1 2014 |
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Keywords
- Cervix
- Diagnosis
- Lymphoma
- Treatment
- Uterus
- Vaginal bleeding
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Primary diffuse large B-cell lymphoma of the uterus : Case report and review. / Mandato, Vincenzo Dario; Palermo, Rosalba; Falbo, Angela; Capodanno, Isabella; Capodanno, Francesco; Gelli, Maria Carolina; Aguzzoli, Lorenzo; Abrate, Martino; La Sala, Giovanni Battista.
In: Anticancer Research, Vol. 34, No. 8, 01.08.2014, p. 4377-4390.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Primary diffuse large B-cell lymphoma of the uterus
T2 - Case report and review
AU - Mandato, Vincenzo Dario
AU - Palermo, Rosalba
AU - Falbo, Angela
AU - Capodanno, Isabella
AU - Capodanno, Francesco
AU - Gelli, Maria Carolina
AU - Aguzzoli, Lorenzo
AU - Abrate, Martino
AU - La Sala, Giovanni Battista
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.
AB - Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.
KW - Cervix
KW - Diagnosis
KW - Lymphoma
KW - Treatment
KW - Uterus
KW - Vaginal bleeding
UR - http://www.scopus.com/inward/record.url?scp=84908673674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84908673674&partnerID=8YFLogxK
M3 - Article
C2 - 25075075
AN - SCOPUS:84908673674
VL - 34
SP - 4377
EP - 4390
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 8
ER -