Primary diffuse large B-cell lymphoma of the uterus: Case report and review

Vincenzo Dario Mandato, Rosalba Palermo, Angela Falbo, Isabella Capodanno, Francesco Capodanno, Maria Carolina Gelli, Lorenzo Aguzzoli, Martino Abrate, Giovanni Battista La Sala

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized. Case Report: Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed. Conclusion: Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.

Original languageEnglish
Pages (from-to)4377-4390
Number of pages14
JournalAnticancer Research
Volume34
Issue number8
Publication statusPublished - Aug 1 2014

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Uterus
Cervix Uteri
Myoma
Rare Diseases
Diagnostic Errors
Radiotherapy
Therapeutics
Safety
Neoplasms

Keywords

  • Cervix
  • Diagnosis
  • Lymphoma
  • Treatment
  • Uterus
  • Vaginal bleeding

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Primary diffuse large B-cell lymphoma of the uterus : Case report and review. / Mandato, Vincenzo Dario; Palermo, Rosalba; Falbo, Angela; Capodanno, Isabella; Capodanno, Francesco; Gelli, Maria Carolina; Aguzzoli, Lorenzo; Abrate, Martino; La Sala, Giovanni Battista.

In: Anticancer Research, Vol. 34, No. 8, 01.08.2014, p. 4377-4390.

Research output: Contribution to journalArticle

Mandato, VD, Palermo, R, Falbo, A, Capodanno, I, Capodanno, F, Gelli, MC, Aguzzoli, L, Abrate, M & La Sala, GB 2014, 'Primary diffuse large B-cell lymphoma of the uterus: Case report and review', Anticancer Research, vol. 34, no. 8, pp. 4377-4390.
Mandato VD, Palermo R, Falbo A, Capodanno I, Capodanno F, Gelli MC et al. Primary diffuse large B-cell lymphoma of the uterus: Case report and review. Anticancer Research. 2014 Aug 1;34(8):4377-4390.
Mandato, Vincenzo Dario ; Palermo, Rosalba ; Falbo, Angela ; Capodanno, Isabella ; Capodanno, Francesco ; Gelli, Maria Carolina ; Aguzzoli, Lorenzo ; Abrate, Martino ; La Sala, Giovanni Battista. / Primary diffuse large B-cell lymphoma of the uterus : Case report and review. In: Anticancer Research. 2014 ; Vol. 34, No. 8. pp. 4377-4390.
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