Primary diffuse meningeal melanomatosis: Radiologic-pathologic correlation

Maria Giulia Pirini, Mario Mascalchi, Fabrizio Salvi, Carlo A. Tassinari, Licciana Zanella, Patrizia Bacchini, Franco Bertoni, Antonia D'Errico, Barbara Corti, Walter F. Grigioni

Research output: Contribution to journalArticlepeer-review


We report a case of primary diffuse meningeal melanomatosis, a rare variant of primary malignant melanoma of the CNS, in a 68-year-old woman. The disease mimicked intracranial hypotension syndrome and was diagnosed only at autopsy (CSF cytologic results were negative). CT revealed hydrocephalus with effacement of the cerebral convexity sulci and abnormal contrast enhancement in the right sylvian and frontoparietal fissures, whereas MR imaging showed diffuse marked dural and leptomeningeal contrast enhancement. In retrospect, these nonspecific findings correlated with the extensive leptomeningeal invasion in the cerebral hemispheres, brain stem and spinal cord. The clinical, radiologic, and pathologic features of diffuse meningeal melanomatosis are reviewed.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number1
Publication statusPublished - Jan 2003

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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