TY - JOUR
T1 - Primary diffuse meningeal melanomatosis
T2 - Radiologic-pathologic correlation
AU - Pirini, Maria Giulia
AU - Mascalchi, Mario
AU - Salvi, Fabrizio
AU - Tassinari, Carlo A.
AU - Zanella, Licciana
AU - Bacchini, Patrizia
AU - Bertoni, Franco
AU - D'Errico, Antonia
AU - Corti, Barbara
AU - Grigioni, Walter F.
PY - 2003/1
Y1 - 2003/1
N2 - We report a case of primary diffuse meningeal melanomatosis, a rare variant of primary malignant melanoma of the CNS, in a 68-year-old woman. The disease mimicked intracranial hypotension syndrome and was diagnosed only at autopsy (CSF cytologic results were negative). CT revealed hydrocephalus with effacement of the cerebral convexity sulci and abnormal contrast enhancement in the right sylvian and frontoparietal fissures, whereas MR imaging showed diffuse marked dural and leptomeningeal contrast enhancement. In retrospect, these nonspecific findings correlated with the extensive leptomeningeal invasion in the cerebral hemispheres, brain stem and spinal cord. The clinical, radiologic, and pathologic features of diffuse meningeal melanomatosis are reviewed.
AB - We report a case of primary diffuse meningeal melanomatosis, a rare variant of primary malignant melanoma of the CNS, in a 68-year-old woman. The disease mimicked intracranial hypotension syndrome and was diagnosed only at autopsy (CSF cytologic results were negative). CT revealed hydrocephalus with effacement of the cerebral convexity sulci and abnormal contrast enhancement in the right sylvian and frontoparietal fissures, whereas MR imaging showed diffuse marked dural and leptomeningeal contrast enhancement. In retrospect, these nonspecific findings correlated with the extensive leptomeningeal invasion in the cerebral hemispheres, brain stem and spinal cord. The clinical, radiologic, and pathologic features of diffuse meningeal melanomatosis are reviewed.
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M3 - Article
C2 - 12533338
AN - SCOPUS:0037237415
VL - 24
SP - 115
EP - 118
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 1
ER -