Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus related cirrhosis

Valeria Ascoli, Francesco Lo Coco, Marco Artini, Massimo Levrero, Alberto Fruscalzo, Cristina Mecucci

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma through yet unknown pathogenetic mechanisms. We describe the case of a patient with HCV-related cirrhosis who developed a primary effusion lymphoma (PEL) of Burkitt's type confined to the peritoneal cavity, in the absence of immunodeficiency or autoimmunity. Paracentesis followed by immunophenotyping, karyotyping, and molecular studies allowed us to diagnose a small noncleaved B-cell lymphoma (CD20+, CD24+, CD10+, CD5-, CD23-, λ+) with the t(8;22) (q24;q11) translocation and clonal rearrangement of the immunoglobulin heavy chain gene. HCV-RNA, Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus were not identified within lymphoma cells. The finding of HCV-RNA in the ascitic fluid suggests a link between HCV and development of lymphoma with HCV playing the role of persistent antigenic stimulation to intraperitoneal B-cell clonal expansion(s).

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalHuman Pathology
Volume28
Issue number1
DOIs
Publication statusPublished - 1997

    Fingerprint

Keywords

  • B-cell
  • Burkitt's lymphoma
  • effusion
  • extranodal lymphoma
  • hepatitis C virus
  • peritoneal cavity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this