Primary gastrointestinal stromal tumor of the liver with lung metastases successfully treated with STI-571 (imatinib mesylate)

Annarosaria De Chiara, Vincenzo De Rosa, Secondo Lastoria, Renato Franco, Gerardo Botti, Vincenzo Rosario Iaffaioli, Gaetano Apice

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of a primary malignant GIST of the liver metastatic to the lung in a 37 years-old man. The liver tumor showed histological feature of a GIST and expressed vimentin, and diffusely exhibited CD117. One year after the resection of the liver mass, the patient developed multiple small lung metastases which completely disappeared with STI-571 (imatinib mesylate - Gleevec) therapy. C.T. or PET did not show any mass in the abdomen. These findings suggest that the liver mass was a primary rather than a metastatic tumour. They also support the hypothesis that GIST could originate from undifferentiated mesenchymal cells capable to differentiate toward a pacemaker cell phenotype, which are present in sites other than the G.I. tract.

Original languageEnglish
Pages (from-to)498-501
Number of pages4
JournalFrontiers in Bioscience
Volume11
Issue number1 P.447-888
DOIs
Publication statusPublished - 2006

Keywords

  • GIST
  • Gleevec
  • Liver
  • Lung Metastases
  • Malignant

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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