Abstract
We report a case of a primary malignant GIST of the liver metastatic to the lung in a 37 years-old man. The liver tumor showed histological feature of a GIST and expressed vimentin, and diffusely exhibited CD117. One year after the resection of the liver mass, the patient developed multiple small lung metastases which completely disappeared with STI-571 (imatinib mesylate - Gleevec) therapy. C.T. or PET did not show any mass in the abdomen. These findings suggest that the liver mass was a primary rather than a metastatic tumour. They also support the hypothesis that GIST could originate from undifferentiated mesenchymal cells capable to differentiate toward a pacemaker cell phenotype, which are present in sites other than the G.I. tract.
Original language | English |
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Pages (from-to) | 498-501 |
Number of pages | 4 |
Journal | Frontiers in Bioscience |
Volume | 11 |
Issue number | 1 P.447-888 |
DOIs | |
Publication status | Published - 2006 |
Keywords
- GIST
- Gleevec
- Liver
- Lung Metastases
- Malignant
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology